4Q2E
CRYSTAL STRUCTURE OF AN INTRAMEMBRANE CDP-DAG SYNTHETASE CENTRAL FOR PHOSPHOLIPID BIOSYNTHESIS (S200C/S258C, active mutant)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004605 | molecular_function | phosphatidate cytidylyltransferase activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0008654 | biological_process | phospholipid biosynthetic process |
| A | 0016024 | biological_process | CDP-diacylglycerol biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| B | 0004605 | molecular_function | phosphatidate cytidylyltransferase activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0008654 | biological_process | phospholipid biosynthetic process |
| B | 0016024 | biological_process | CDP-diacylglycerol biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016779 | molecular_function | nucleotidyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE HG A 301 |
| Chain | Residue |
| A | CYS220 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE HG A 302 |
| Chain | Residue |
| A | PHE37 |
| A | CYS41 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE HG A 303 |
| Chain | Residue |
| A | TYR183 |
| A | CYS243 |
| A | LYS246 |
| A | ARG247 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 304 |
| Chain | Residue |
| A | ASP269 |
| A | GLY270 |
| A | ASP164 |
| A | ASP239 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K A 305 |
| Chain | Residue |
| A | ASP239 |
| A | GLU242 |
| A | CYS243 |
| A | ASP269 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE HG B 301 |
| Chain | Residue |
| B | CYS220 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE HG B 302 |
| Chain | Residue |
| B | PHE37 |
| B | CYS41 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE HG B 303 |
| Chain | Residue |
| B | TYR183 |
| B | CYS243 |
| B | LYS246 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 304 |
| Chain | Residue |
| B | ASP164 |
| B | ASP239 |
| B | ASP269 |
| B | GLY270 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE K B 305 |
| Chain | Residue |
| B | ASP239 |
| B | GLU242 |
| B | ASP269 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 320 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
