Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4PZE

Crystal structure of (S)-3-hydroxybutyryl-CoA dehydrogenase PaaH1 in complex with acetoacetyl-CoA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0003857	molecular_function	(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
A	0006631	biological_process	fatty acid metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0032787	biological_process	monocarboxylic acid metabolic process
A	0070403	molecular_function	NAD+ binding
B	0000166	molecular_function	nucleotide binding
B	0003824	molecular_function	catalytic activity
B	0003857	molecular_function	(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
B	0006631	biological_process	fatty acid metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0032787	biological_process	monocarboxylic acid metabolic process
B	0070403	molecular_function	NAD+ binding
C	0000166	molecular_function	nucleotide binding
C	0003824	molecular_function	catalytic activity
C	0003857	molecular_function	(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
C	0006631	biological_process	fatty acid metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0032787	biological_process	monocarboxylic acid metabolic process
C	0070403	molecular_function	NAD+ binding
D	0000166	molecular_function	nucleotide binding
D	0003824	molecular_function	catalytic activity
D	0003857	molecular_function	(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
D	0006631	biological_process	fatty acid metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0032787	biological_process	monocarboxylic acid metabolic process
D	0070403	molecular_function	NAD+ binding
E	0000166	molecular_function	nucleotide binding
E	0003824	molecular_function	catalytic activity
E	0003857	molecular_function	(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
E	0006631	biological_process	fatty acid metabolic process
E	0016491	molecular_function	oxidoreductase activity
E	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E	0032787	biological_process	monocarboxylic acid metabolic process
E	0070403	molecular_function	NAD+ binding
F	0000166	molecular_function	nucleotide binding
F	0003824	molecular_function	catalytic activity
F	0003857	molecular_function	(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
F	0006631	biological_process	fatty acid metabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F	0032787	biological_process	monocarboxylic acid metabolic process
F	0070403	molecular_function	NAD+ binding
G	0000166	molecular_function	nucleotide binding
G	0003824	molecular_function	catalytic activity
G	0003857	molecular_function	(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
G	0006631	biological_process	fatty acid metabolic process
G	0016491	molecular_function	oxidoreductase activity
G	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
G	0032787	biological_process	monocarboxylic acid metabolic process
G	0070403	molecular_function	NAD+ binding
H	0000166	molecular_function	nucleotide binding
H	0003824	molecular_function	catalytic activity
H	0003857	molecular_function	(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
H	0006631	biological_process	fatty acid metabolic process
H	0016491	molecular_function	oxidoreductase activity
H	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
H	0032787	biological_process	monocarboxylic acid metabolic process
H	0070403	molecular_function	NAD+ binding
I	0000166	molecular_function	nucleotide binding
I	0003824	molecular_function	catalytic activity
I	0003857	molecular_function	(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
I	0006631	biological_process	fatty acid metabolic process
I	0016491	molecular_function	oxidoreductase activity
I	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
I	0032787	biological_process	monocarboxylic acid metabolic process
I	0070403	molecular_function	NAD+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CAA A 301

Chain	Residue
A	SER119
A	PHE142
A	ASN190
A	GLY221
A	CYS222
A	ASN223
A	ILE226

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE CAA B 301

Chain	Residue
B	VAL147
B	ASN190
B	PRO225
B	ILE235
C	GLY221
C	CYS222
C	ASN223
I	SER131
I	ARG135
B	ARG52
B	LYS58

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE CAA C 301

Chain	Residue
B	GLY221
B	CYS222
B	ASN223
C	LYS56
C	SER119
C	HIS140
C	ASN143
C	PRO144
C	MET148
C	ASN190
C	PRO225
C	ILE226
C	ILE235
C	HOH407

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CAA D 301

Chain	Residue
D	SER119
D	HIS140
D	ASN143
D	ASN190
D	LEU231
G	GLY221
G	CYS222
G	ASN223

site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE CAA E 301

Chain	Residue
C	GLU110
C	ARG135
E	ARG52
E	SER119
E	PHE142
E	VAL147
E	ASN190
E	PRO225
E	ILE226
E	LEU231
F	GLY221
F	CYS222
F	ASN223

site_id	AC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE CAA F 301

Chain	Residue
E	GLY221
E	CYS222
E	ASN223
F	ARG52
F	LYS56
F	SER119
F	HIS140
F	PHE142
F	ASN143
F	PRO144
F	MET148
F	ASN190
F	LEU231
F	MET234
F	HOH421

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CAA G 301

Chain	Residue
D	GLY221
D	ASN223
G	SER119
G	HIS140
G	PHE142
G	MET148
G	ASN190
G	ILE235
G	THR239

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CAA H 301

Chain	Residue
H	SER119
H	VAL147
H	ASN190
H	LEU193
H	PRO225
H	LEU231
H	THR239
I	GLY221
I	ASN223

site_id	AC9
Number of Residues	16
Details	BINDING SITE FOR RESIDUE CAA I 301

Chain	Residue
I	MET234
I	ILE235
I	ARG273
H	GLY221
H	ASN223
I	ARG52
I	SER119
I	HIS140
I	PHE141
I	PHE142
I	ASN143
I	PRO144
I	ASN190
I	PRO225
I	ILE226
I	LEU231

Functional Information from PROSITE/UniProt

site_id	PS00067
Number of Residues	25
Details	3HCDH 3-hydroxyacyl-CoA dehydrogenase signature. NspGFVvNRilcPMIneafc.VLgeG

Chain	Residue	Details
A	ASN183-GLY207

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)