Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4PZD

Crystal structure of (S)-3-hydroxybutyryl-CoA dehydrogenase PaaH1 in complex with NAD+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003857	molecular_function	3-hydroxyacyl-CoA dehydrogenase activity
A	0006631	biological_process	fatty acid metabolic process
A	0006635	biological_process	fatty acid beta-oxidation
A	0008691	molecular_function	3-hydroxybutyryl-CoA dehydrogenase activity
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0044248	biological_process	cellular catabolic process
A	0070403	molecular_function	NAD+ binding
A	1901575	biological_process	organic substance catabolic process
B	0000166	molecular_function	nucleotide binding
B	0003857	molecular_function	3-hydroxyacyl-CoA dehydrogenase activity
B	0006631	biological_process	fatty acid metabolic process
B	0006635	biological_process	fatty acid beta-oxidation
B	0008691	molecular_function	3-hydroxybutyryl-CoA dehydrogenase activity
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0044248	biological_process	cellular catabolic process
B	0070403	molecular_function	NAD+ binding
B	1901575	biological_process	organic substance catabolic process
C	0000166	molecular_function	nucleotide binding
C	0003857	molecular_function	3-hydroxyacyl-CoA dehydrogenase activity
C	0006631	biological_process	fatty acid metabolic process
C	0006635	biological_process	fatty acid beta-oxidation
C	0008691	molecular_function	3-hydroxybutyryl-CoA dehydrogenase activity
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0044248	biological_process	cellular catabolic process
C	0070403	molecular_function	NAD+ binding
C	1901575	biological_process	organic substance catabolic process
D	0000166	molecular_function	nucleotide binding
D	0003857	molecular_function	3-hydroxyacyl-CoA dehydrogenase activity
D	0006631	biological_process	fatty acid metabolic process
D	0006635	biological_process	fatty acid beta-oxidation
D	0008691	molecular_function	3-hydroxybutyryl-CoA dehydrogenase activity
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0044248	biological_process	cellular catabolic process
D	0070403	molecular_function	NAD+ binding
D	1901575	biological_process	organic substance catabolic process
E	0000166	molecular_function	nucleotide binding
E	0003857	molecular_function	3-hydroxyacyl-CoA dehydrogenase activity
E	0006631	biological_process	fatty acid metabolic process
E	0006635	biological_process	fatty acid beta-oxidation
E	0008691	molecular_function	3-hydroxybutyryl-CoA dehydrogenase activity
E	0016491	molecular_function	oxidoreductase activity
E	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E	0044248	biological_process	cellular catabolic process
E	0070403	molecular_function	NAD+ binding
E	1901575	biological_process	organic substance catabolic process
F	0000166	molecular_function	nucleotide binding
F	0003857	molecular_function	3-hydroxyacyl-CoA dehydrogenase activity
F	0006631	biological_process	fatty acid metabolic process
F	0006635	biological_process	fatty acid beta-oxidation
F	0008691	molecular_function	3-hydroxybutyryl-CoA dehydrogenase activity
F	0016491	molecular_function	oxidoreductase activity
F	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F	0044248	biological_process	cellular catabolic process
F	0070403	molecular_function	NAD+ binding
F	1901575	biological_process	organic substance catabolic process
G	0000166	molecular_function	nucleotide binding
G	0003857	molecular_function	3-hydroxyacyl-CoA dehydrogenase activity
G	0006631	biological_process	fatty acid metabolic process
G	0006635	biological_process	fatty acid beta-oxidation
G	0008691	molecular_function	3-hydroxybutyryl-CoA dehydrogenase activity
G	0016491	molecular_function	oxidoreductase activity
G	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
G	0044248	biological_process	cellular catabolic process
G	0070403	molecular_function	NAD+ binding
G	1901575	biological_process	organic substance catabolic process
H	0000166	molecular_function	nucleotide binding
H	0003857	molecular_function	3-hydroxyacyl-CoA dehydrogenase activity
H	0006631	biological_process	fatty acid metabolic process
H	0006635	biological_process	fatty acid beta-oxidation
H	0008691	molecular_function	3-hydroxybutyryl-CoA dehydrogenase activity
H	0016491	molecular_function	oxidoreductase activity
H	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
H	0044248	biological_process	cellular catabolic process
H	0070403	molecular_function	NAD+ binding
H	1901575	biological_process	organic substance catabolic process
I	0000166	molecular_function	nucleotide binding
I	0003857	molecular_function	3-hydroxyacyl-CoA dehydrogenase activity
I	0006631	biological_process	fatty acid metabolic process
I	0006635	biological_process	fatty acid beta-oxidation
I	0008691	molecular_function	3-hydroxybutyryl-CoA dehydrogenase activity
I	0016491	molecular_function	oxidoreductase activity
I	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
I	0044248	biological_process	cellular catabolic process
I	0070403	molecular_function	NAD+ binding
I	1901575	biological_process	organic substance catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE NAD A 301

Chain	Residue
A	VAL9
A	LYS97
A	ILE100
A	ASN117
A	SER119
A	HIS140
A	ASN143
A	GLY12
A	THR13
A	MET14
A	ASP33
A	ALA89
A	ALA90
A	THR91
A	GLU92

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE NAD B 301

Chain	Residue
B	VAL9
B	GLY12
B	THR13
B	MET14
B	ASP33
B	TYR77
B	ALA89
B	ALA90
B	THR91
B	GLU92
B	ASN117
B	THR118
B	SER119
B	HIS140
B	PHE141

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE NAD C 301

Chain	Residue
C	GLY10
C	GLY12
C	THR13
C	MET14
C	ASP33
C	ILE34
C	TYR77
C	ALA89
C	ALA90
C	THR91
C	GLU92
C	ILE100
C	ASN117
C	HIS140
C	ASN143

site_id	AC4
Number of Residues	17
Details	BINDING SITE FOR RESIDUE NAD D 301

Chain	Residue
D	GLY12
D	THR13
D	MET14
D	ASP33
D	ILE34
D	TYR77
D	ALA89
D	ALA90
D	THR91
D	GLU92
D	LYS97
D	ASN117
D	SER119
D	HIS140
D	PHE141
D	ASN143
F	SER283

site_id	AC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE NAD E 301

Chain	Residue
E	GLY12
E	THR13
E	MET14
E	ASP33
E	TYR77
E	ALA89
E	ALA90
E	THR91
E	GLU92
E	LYS97
E	ASN117
E	HIS140
E	PHE141
E	ASN143

site_id	AC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE NAD F 301

Chain	Residue
F	GLY10
F	GLY12
F	THR13
F	MET14
F	ASP33
F	ILE34
F	TYR77
F	ALA89
F	ALA90
F	THR91
F	GLU92
F	ILE100
F	ASN117
F	HOH411

site_id	AC7
Number of Residues	15
Details	BINDING SITE FOR RESIDUE NAD G 301

Chain	Residue
G	GLU92
G	ASN117
G	SER119
G	HIS140
G	ASN143
I	SER283
G	GLY12
G	THR13
G	MET14
G	ASP33
G	ILE34
G	TYR77
G	ALA89
G	ALA90
G	THR91

site_id	AC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE NAD H 301

Chain	Residue
H	GLY12
H	THR13
H	MET14
H	ASP33
H	TYR77
H	ALA89
H	ALA90
H	THR91
H	GLU92
H	ASN117
H	HIS140
H	HOH408

site_id	AC9
Number of Residues	15
Details	BINDING SITE FOR RESIDUE NAD I 301

Chain	Residue
I	GLY10
I	GLY12
I	THR13
I	MET14
I	ASP33
I	ILE34
I	TYR77
I	ALA89
I	ALA90
I	THR91
I	GLU92
I	LYS97
I	ILE100
I	ASN117
I	THR239

Functional Information from PROSITE/UniProt

site_id	PS00067
Number of Residues	25
Details	3HCDH 3-hydroxyacyl-CoA dehydrogenase signature. NspGFVvNRilcPMIneafc.VLgeG

Chain	Residue	Details
A	ASN183-GLY207

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)