4PZ7
PCE1 guanylyltransferase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004484 | molecular_function | mRNA guanylyltransferase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0006370 | biological_process | 7-methylguanosine mRNA capping |
| A | 0006397 | biological_process | mRNA processing |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0031533 | cellular_component | mRNA capping enzyme complex |
| A | 0099122 | molecular_function | RNA polymerase II C-terminal domain binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004484 | molecular_function | mRNA guanylyltransferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0006370 | biological_process | 7-methylguanosine mRNA capping |
| B | 0006397 | biological_process | mRNA processing |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016779 | molecular_function | nucleotidyltransferase activity |
| B | 0031533 | cellular_component | mRNA capping enzyme complex |
| B | 0099122 | molecular_function | RNA polymerase II C-terminal domain binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 501 |
| Chain | Residue |
| A | LYS331 |
| A | ARG332 |
| A | ASP333 |
| A | HOH701 |
| A | HOH737 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 502 |
| Chain | Residue |
| A | HOH701 |
| A | LYS331 |
| A | ASN335 |
| A | HIS336 |
| A | THR339 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 503 |
| Chain | Residue |
| A | PRO243 |
| A | LYS244 |
| A | SER352 |
| A | LYS353 |
| A | HOH632 |
| A | HOH647 |
| A | HOH685 |
| A | HOH711 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 504 |
| Chain | Residue |
| A | PRO133 |
| A | ARG215 |
| A | HOH735 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 505 |
| Chain | Residue |
| A | ARG157 |
| A | LEU158 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 506 |
| Chain | Residue |
| A | ARG157 |
| A | LYS161 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 507 |
| Chain | Residue |
| A | HIS80 |
| A | TYR83 |
| A | ARG86 |
| A | HOH739 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 508 |
| Chain | Residue |
| A | HIS201 |
| A | ARG364 |
| A | TYR368 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 509 |
| Chain | Residue |
| A | ARG72 |
| A | ARG94 |
| A | HOH605 |
| site_id | BC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 A 510 |
| Chain | Residue |
| A | ARG215 |
| site_id | BC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 511 |
| Chain | Residue |
| A | PHE49 |
| A | LYS240 |
| A | TRP241 |
| A | LYS242 |
| A | ASN247 |
| A | GLY350 |
| A | VAL351 |
| A | HOH681 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 512 |
| Chain | Residue |
| A | ILE104 |
| A | PHE105 |
| A | TYR106 |
| A | TYR117 |
| A | HIS118 |
| A | HOH696 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 513 |
| Chain | Residue |
| A | MET252 |
| A | LYS254 |
| A | GLN274 |
| A | GLY276 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 501 |
| Chain | Residue |
| B | LYS331 |
| B | ARG332 |
| B | ASP333 |
| B | HOH631 |
| B | HOH638 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 502 |
| Chain | Residue |
| B | LYS331 |
| B | ASN335 |
| B | HIS336 |
| B | THR339 |
| B | HOH638 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 503 |
| Chain | Residue |
| B | PRO243 |
| B | LYS244 |
| B | SER352 |
| B | LYS353 |
| B | HOH699 |
| B | HOH720 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 504 |
| Chain | Residue |
| B | ARG157 |
| B | LEU158 |
| B | HOH714 |
| B | HOH718 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 505 |
| Chain | Residue |
| B | ARG157 |
| B | LYS161 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 506 |
| Chain | Residue |
| B | HIS201 |
| B | ARG364 |
| B | TYR368 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 507 |
| Chain | Residue |
| B | ARG72 |
| B | ARG94 |
| B | HOH635 |
| B | HOH780 |
| B | HOH793 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 508 |
| Chain | Residue |
| B | ASP250 |
| B | LYS331 |
| B | ASN335 |
| B | HOH735 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 509 |
| Chain | Residue |
| B | HIS80 |
| B | ARG82 |
| B | TYR83 |
| B | ARG86 |
| B | HIS100 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"N6-GMP-lysine intermediate","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
