Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0006584 | biological_process | catecholamine metabolic process |
| A | 0008171 | molecular_function | O-methyltransferase activity |
| A | 0016206 | molecular_function | catechol O-methyltransferase activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0006584 | biological_process | catecholamine metabolic process |
| B | 0008171 | molecular_function | O-methyltransferase activity |
| B | 0016206 | molecular_function | catechol O-methyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE 2X1 A 301 |
| Chain | Residue |
| A | ILE134 |
| A | ASN135 |
| A | PRO136 |
| A | TRP186 |
| A | ASP188 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ACT A 302 |
| Chain | Residue |
| A | TRP186 |
| A | ARG189 |
| A | ASP193 |
| A | HOH440 |
| A | LEU108 |
| A | GLY109 |
| A | SER162 |
| A | ASP184 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 303 |
| Chain | Residue |
| A | VAL226 |
| A | ARG227 |
| A | SER229 |
| A | PHE232 |
| B | GLU242 |
| B | HOH401 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 304 |
| Chain | Residue |
| A | ALA110 |
| A | TYR111 |
| A | CYS112 |
| A | GLY113 |
| A | TYR114 |
| A | SER115 |
| A | ASP184 |
| A | HOH402 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 305 |
| Chain | Residue |
| A | ARG51 |
| A | TYR75 |
| A | LYS79 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 301 |
| Chain | Residue |
| A | GLU242 |
| A | HOH489 |
| B | VAL226 |
| B | ARG227 |
| B | SER229 |
| B | PHE232 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE 2X1 B 302 |
| Chain | Residue |
| B | ILE134 |
| B | ASN135 |
| B | PRO136 |
| B | TRP186 |
| B | ASP188 |
| B | ARG189 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ACT B 303 |
| Chain | Residue |
| B | LEU108 |
| B | GLY109 |
| B | SER162 |
| B | ASP184 |
| B | TRP186 |
| B | ARG189 |
| B | ASP193 |
| B | HOH468 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 304 |
| Chain | Residue |
| B | GLY86 |
| B | ARG118 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 305 |
| Chain | Residue |
| B | TYR111 |
| B | CYS112 |
| B | GLY113 |
| B | TYR114 |
| B | SER115 |
| B | ASP184 |
| B | HOH427 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 306 |
| Chain | Residue |
| B | ARG51 |
| B | TYR75 |
| B | LYS79 |
| B | HOH466 |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| B | GLU133 | |
| B | ASP184 | |
| A | VAL85 | |
| A | SER115 | |
| A | GLU133 | |
| A | ASP184 | |
| B | VAL85 | |
| B | SER115 | |
| Chain | Residue | Details |
| A | SER162 | |
| B | GLU107 | |
| B | ILE134 | |
| B | SER162 | |
| A | GLU107 | |
| A | ILE134 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ASP212 | |
| A | ASN213 | |
| A | GLU242 | |
| B | GLY160 | |
| B | LYS187 | |
| B | ASP212 | |
| B | ASN213 | |
| B | GLU242 | |
| A | LYS187 | |
| A | GLY160 | |
| Chain | Residue | Details |
| B | SER259 | |
| B | SER260 | |
| B | SER264 | |
| A | SER259 | |
| A | SER260 | |
| A | SER264 | |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 915 |
| Chain | Residue | Details |
| A | ASP184 | metal ligand |
| A | LYS187 | proton shuttle (general acid/base) |
| A | ASP212 | metal ligand |
| A | ASN213 | metal ligand |
| A | GLU242 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 915 |
| Chain | Residue | Details |
| B | ASP184 | metal ligand |
| B | LYS187 | proton shuttle (general acid/base) |
| B | ASP212 | metal ligand |
| B | ASN213 | metal ligand |
| B | GLU242 | electrostatic stabiliser |
