4PXO
Crystal structure of Maleylacetoacetate isomerase from Methylobacteriu extorquens AM1 WITH BOUND MALONATE AND GSH (TARGET EFI-507068)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004364 | molecular_function | glutathione transferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006559 | biological_process | L-phenylalanine catabolic process |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0009072 | biological_process | aromatic amino acid metabolic process |
| A | 0016034 | molecular_function | maleylacetoacetate isomerase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016853 | molecular_function | isomerase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004364 | molecular_function | glutathione transferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006559 | biological_process | L-phenylalanine catabolic process |
| B | 0006749 | biological_process | glutathione metabolic process |
| B | 0009072 | biological_process | aromatic amino acid metabolic process |
| B | 0016034 | molecular_function | maleylacetoacetate isomerase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016853 | molecular_function | isomerase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MLA A 301 |
| Chain | Residue |
| A | ARG8 |
| A | ALA10 |
| A | HIS105 |
| A | PRO110 |
| A | ARG113 |
| A | GSH302 |
| A | EDO304 |
| A | HOH459 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE GSH A 302 |
| Chain | Residue |
| A | ALA10 |
| A | ALA11 |
| A | ARG14 |
| A | LEU33 |
| A | GLN38 |
| A | ALA51 |
| A | VAL52 |
| A | PRO53 |
| A | GLN65 |
| A | SER66 |
| A | HIS105 |
| A | PRO110 |
| A | ARG111 |
| A | MLA301 |
| A | HOH415 |
| A | HOH420 |
| A | HOH435 |
| A | HOH455 |
| A | HOH594 |
| B | CYS102 |
| B | ASP103 |
| A | SER9 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 303 |
| Chain | Residue |
| A | ARG154 |
| A | ARG154 |
| A | GLU194 |
| A | ALA197 |
| A | LEU198 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 304 |
| Chain | Residue |
| A | ARG8 |
| A | ALA10 |
| A | SER170 |
| A | VAL173 |
| A | ILE177 |
| A | PHE178 |
| A | MLA301 |
| A | HOH413 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 305 |
| Chain | Residue |
| A | TRP7 |
| A | TYR72 |
| A | PRO213 |
| B | GLU86 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MLA B 301 |
| Chain | Residue |
| B | ARG8 |
| B | ALA10 |
| B | HIS105 |
| B | ARG113 |
| B | GSH302 |
| B | EDO307 |
| B | HOH472 |
| site_id | AC7 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE GSH B 302 |
| Chain | Residue |
| A | CYS102 |
| A | ASP103 |
| A | HOH443 |
| B | SER9 |
| B | ALA10 |
| B | ALA11 |
| B | ARG14 |
| B | LEU33 |
| B | GLN38 |
| B | GLY50 |
| B | ALA51 |
| B | VAL52 |
| B | PRO53 |
| B | GLN65 |
| B | SER66 |
| B | HIS105 |
| B | VAL109 |
| B | PRO110 |
| B | ARG111 |
| B | MLA301 |
| B | EDO304 |
| B | HOH406 |
| B | HOH414 |
| B | HOH426 |
| B | HOH533 |
| B | HOH535 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 303 |
| Chain | Residue |
| A | LEU107 |
| A | PHE130 |
| A | ASN133 |
| A | ALA134 |
| B | ARG111 |
| B | VAL112 |
| B | PHE115 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 304 |
| Chain | Residue |
| A | HOH539 |
| B | GLN49 |
| B | VAL109 |
| B | ARG111 |
| B | GSH302 |
| B | HOH422 |
| B | HOH534 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 305 |
| Chain | Residue |
| B | HOH556 |
| A | PHE115 |
| B | PHE130 |
| B | ASN133 |
| B | ALA134 |
| B | HOH519 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 306 |
| Chain | Residue |
| B | ASN20 |
| B | ALA200 |
| B | HOH438 |
| B | HOH489 |
| B | HOH563 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 307 |
| Chain | Residue |
| B | ARG8 |
| B | ALA10 |
| B | TYR108 |
| B | ILE177 |
| B | MLA301 |
| B | HOH413 |
