4PWD
Crystal structure of HIV-1 reverse transcriptase in complex with bulge-RNA/DNA and Nevirapine
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003676 | molecular_function | nucleic acid binding |
A | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
A | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
A | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
B | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
B | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
C | 0003676 | molecular_function | nucleic acid binding |
C | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
C | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
C | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
D | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
D | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE NVP A 901 |
Chain | Residue |
A | LEU100 |
A | LYS101 |
A | VAL179 |
A | TYR181 |
A | TYR188 |
A | TRP229 |
A | LEU234 |
site_id | AC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CA A 902 |
Chain | Residue |
A | ASP443 |
A | ASP549 |
site_id | AC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 B 501 |
Chain | Residue |
B | TRP24 |
B | GLU399 |
B | TRP402 |
site_id | AC4 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE NVP C 901 |
Chain | Residue |
C | LYS101 |
C | VAL106 |
C | VAL179 |
C | TYR181 |
C | TYR188 |
C | TRP229 |
C | LEU234 |
C | HIS235 |
C | PRO236 |
C | TYR318 |
site_id | AC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CA C 902 |
Chain | Residue |
C | ASP443 |
C | GLY444 |
C | ASP549 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | BINDING: |
Chain | Residue | Details |
B | ASP110 | |
B | ASP185 | |
B | ASP186 | |
D | ASP110 | |
D | ASP185 | |
D | ASP186 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | SITE: Essential for RT p66/p51 heterodimerization |
Chain | Residue | Details |
B | TRP401 | |
B | TRP414 | |
D | TRP401 | |
D | TRP414 | |
C | ASP443 | |
C | GLU478 | |
C | ASN498 | |
C | ASP549 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | SITE: Essential for RT p66/p51 heterodimerization |
Chain | Residue | Details |
A | TRP401 | |
A | TRP414 | |
C | TRP401 | |
C | TRP414 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | SITE: Cleavage; by viral protease; partial |
Chain | Residue | Details |
A | PHE440 | |
C | PHE440 |