4PVB

Crystal structure of Aminopeptidase N in complex with the phosphonic acid analogue of leucine (D-(S)-LeuP)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004177	molecular_function	aminopeptidase activity
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 2WW A 1001

Chain	Residue
A	GLN115
A	GLU316
A	TYR372
A	TYR377
A	ZN1002
A	GLU117
A	ALA258
A	MSE259
A	GLU260
A	HIS293
A	GLU294
A	HIS297
A	LYS315

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1002

Chain	Residue
A	HIS293
A	HIS297
A	GLU316
A	2WW1001

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site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1003

Chain	Residue
A	MSE469
A	THR470
A	ASP471
A	HOH1412
A	HOH1413

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site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1004

Chain	Residue
A	ARG822
A	HOH1299
A	HOH1300
A	HOH1403

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site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 A 1005

Chain	Residue
A	ARG406

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site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 A 1006

Chain	Residue
A	ARG330

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site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 1007

Chain	Residue
A	ARG277
A	LYS736

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site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 A 1008

Chain	Residue
A	ARG636
A	LEU640
A	ARG755

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Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVGHEYFHNW

Chain	Residue	Details
A	VAL290-TRP299

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