4PU2

Crystal structure of Aminopeptidase N in complex with the phosphonic acid analogue of leucine L-(R)-LeuP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004177	molecular_function	aminopeptidase activity
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0016285	molecular_function	alanyl aminopeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE PLU A 901

Chain	Residue
A	GLN115
A	LYS315
A	GLU316
A	TYR372
A	TYR377
A	ZN904
A	HOH1170
A	GLU117
A	MSE256
A	ALA258
A	MSE259
A	GLU260
A	HIS293
A	GLU294
A	HIS297

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 902

Chain	Residue
A	PRO585
A	LYS586
A	HIS587
A	GLU588
A	LYS589

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site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 903

Chain	Residue
A	PRO649
A	ARG764
A	LEU767
A	PHE804
A	LYS808
A	HOH1240

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site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 904

Chain	Residue
A	HIS293
A	HIS297
A	GLU316
A	PLU901

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site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 905

Chain	Residue
A	MSE469
A	THR470
A	ASP471
A	HOH1235

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site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 906

Chain	Residue
A	ARG636
A	ARG755
A	HOH1076
A	HOH1172

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 907

Chain	Residue
A	THR565
A	ARG569

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site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 908

Chain	Residue
A	LEU402
A	ARG406

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site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 909

Chain	Residue
A	ASN655
A	ARG679
A	ARG683
A	LYS700
A	MSE704

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