Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE FOL A 201 |
| Chain | Residue |
| A | ALA6 |
| A | LEU54 |
| A | ILE94 |
| A | THR113 |
| A | NAP202 |
| A | HOH307 |
| A | HOH326 |
| A | HOH335 |
| A | HOH351 |
| A | HOH429 |
| A | HOH470 |
| A | ALA7 |
| A | HOH471 |
| A | HOH482 |
| A | HOH524 |
| A | HOH596 |
| A | HOH598 |
| A | MET20 |
| A | ASP27 |
| A | LEU28 |
| A | ALA29 |
| A | PHE31 |
| A | LYS32 |
| A | ILE50 |
| site_id | AC2 |
| Number of Residues | 40 |
| Details | BINDING SITE FOR RESIDUE NAP A 202 |
| Chain | Residue |
| A | ALA6 |
| A | ALA7 |
| A | ILE14 |
| A | GLY15 |
| A | ASN18 |
| A | ALA19 |
| A | MET20 |
| A | TRP22 |
| A | GLY43 |
| A | ARG44 |
| A | HIS45 |
| A | THR46 |
| A | SER49 |
| A | LEU62 |
| A | SER63 |
| A | LYS76 |
| A | VAL78 |
| A | ILE94 |
| A | GLY96 |
| A | GLY97 |
| A | ARG98 |
| A | VAL99 |
| A | TYR100 |
| A | GLN102 |
| A | THR123 |
| A | ASP131 |
| A | FOL201 |
| A | HOH314 |
| A | HOH334 |
| A | HOH339 |
| A | HOH347 |
| A | HOH351 |
| A | HOH357 |
| A | HOH385 |
| A | HOH510 |
| A | HOH539 |
| A | HOH552 |
| A | HOH585 |
| A | HOH592 |
| A | HOH644 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 203 |
| Chain | Residue |
| A | ASP116 |
| A | HIS149 |
| A | ARG159 |
| A | HOH572 |
| A | HOH573 |
| A | HOH588 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 204 |
| Chain | Residue |
| A | GLU154 |
| A | HOH566 |
| A | HOH567 |
| A | HOH568 |
| A | HOH569 |
| A | HOH570 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 23 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGmenaMPWnlpa.DlawFkrnT |
| Chain | Residue | Details |
| A | VAL13-THR35 | |
