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4PRX

E. coli GyrB 43-kDa N-terminal fragment in complex with ADP+Pi

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0003918molecular_functionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A0005524molecular_functionATP binding
A0006265biological_processDNA topological change
Functional Information from PDB Data
site_idAC1
Number of Residues27
DetailsBINDING SITE FOR RESIDUE ADP A 401
ChainResidue
ATYR5
AGLY102
ALYS103
ATYR109
AGLY114
ALEU115
AHIS116
AGLY117
AVAL118
AGLY119
AVAL120
AILE10
ATHR165
APO4402
AMG403
AHOH502
AHOH504
AHOH505
AHOH511
AHOH535
AASN46
AGLU50
AASP73
AILE78
AILE94
AALA100
AGLY101

site_idAC2
Number of Residues11
DetailsBINDING SITE FOR RESIDUE PO4 A 402
ChainResidue
AGLU42
ALEU115
AHIS116
AGLY117
AVAL118
AGLY119
ALYS337
AADP401
AMG403
AHOH543
AHOH646

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG A 403
ChainResidue
AASN46
AADP401
APO4402
AHOH642

site_idAC4
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GOL A 404
ChainResidue
ATRP170
ALYS223
AASN239
AILE240
APHE241
ATYR242
AHOH563
AHOH575
AHOH587

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor (ATPase activity) => ECO:0000305|PubMed:10734094, ECO:0000305|PubMed:8248233
ChainResidueDetails
AGLU42

site_idSWS_FT_FI2
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:25202966, ECO:0000269|PubMed:25849408, ECO:0000305|PubMed:10734094
ChainResidueDetails
ATYR5

site_idSWS_FT_FI3
Number of Residues5
DetailsBINDING: BINDING => ECO:0000269|PubMed:10734094, ECO:0000269|PubMed:25202966, ECO:0000269|PubMed:25849408
ChainResidueDetails
AASN46
AASP73
AGLY102
ATYR109
ALEU115

site_idSWS_FT_FI4
Number of Residues7
DetailsBINDING: BINDING => ECO:0000269|PubMed:25849408
ChainResidueDetails
AILE94
AVAL97
AALA100
ALYS103
AASP105
AGLY117
ASER121

site_idSWS_FT_FI5
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:10734094, ECO:0000269|PubMed:25849408
ChainResidueDetails
AGLN335

site_idSWS_FT_FI6
Number of Residues1
DetailsSITE: Transition state stabilizer => ECO:0000305|PubMed:9657678
ChainResidueDetails
ALYS337

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PDB entries from 2024-10-30

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