4PRX

E. coli GyrB 43-kDa N-terminal fragment in complex with ADP+Pi

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A	0005524	molecular_function	ATP binding
A	0006265	biological_process	DNA topological change

Functional Information from PDB Data

site_id	AC1
Number of Residues	27
Details	BINDING SITE FOR RESIDUE ADP A 401

Chain	Residue
A	TYR5
A	GLY102
A	LYS103
A	TYR109
A	GLY114
A	LEU115
A	HIS116
A	GLY117
A	VAL118
A	GLY119
A	VAL120
A	ILE10
A	THR165
A	PO4402
A	MG403
A	HOH502
A	HOH504
A	HOH505
A	HOH511
A	HOH535
A	ASN46
A	GLU50
A	ASP73
A	ILE78
A	ILE94
A	ALA100
A	GLY101

---

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PO4 A 402

Chain	Residue
A	GLU42
A	LEU115
A	HIS116
A	GLY117
A	VAL118
A	GLY119
A	LYS337
A	ADP401
A	MG403
A	HOH543
A	HOH646

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 403

Chain	Residue
A	ASN46
A	ADP401
A	PO4402
A	HOH642

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 404

Chain	Residue
A	TRP170
A	LYS223
A	ASN239
A	ILE240
A	PHE241
A	TYR242
A	HOH563
A	HOH575
A	HOH587

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor (ATPase activity)","evidences":[{"source":"PubMed","id":"10734094","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"8248233","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25202966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25849408","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10734094","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10734094","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25202966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25849408","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25849408","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10734094","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25849408","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"9657678","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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