4PPR

Crystal structure of Mycobacterium tuberculosis D,D-peptidase Rv3330 in complex with meropenem

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0009002	molecular_function	serine-type D-Ala-D-Ala carboxypeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE MER A 400

Chain	Residue
A	ALA120
A	GLY284
A	TYR285
A	GLN291
A	ARG313
A	HOH553
A	SER121
A	THR153
A	SER176
A	ASN178
A	GLY217
A	LEU218
A	LYS282
A	THR283

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Acyl-ester intermediate => ECO:0000305|PubMed:25551456

Chain	Residue	Details
A	SER121

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P0AEB2

Chain	Residue	Details
A	LYS124

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site_id	SWS_FT_FI3
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P0AEB2

Chain	Residue	Details
A	SER176

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by PknH => ECO:0000269|PubMed:17286964

Chain	Residue	Details
A	THR336

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