Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| A | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue 31V A 801 |
| Chain | Residue |
| A | ALA542 |
| A | MET592 |
| A | HIS648 |
| A | LEU657 |
| A | ASP668 |
| A | PHE669 |
| A | HOH917 |
| A | LYS544 |
| A | GLU560 |
| A | LEU563 |
| A | LEU564 |
| A | LEU567 |
| A | PHE589 |
| A | GLU590 |
| A | TYR591 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 802 |
| Chain | Residue |
| A | PRO754 |
| A | PRO754 |
| A | GLU755 |
| A | HOH931 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 803 |
| Chain | Residue |
| A | ARG761 |
| A | ARG761 |
| A | HOH931 |
| A | HOH931 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 804 |
| Chain | Residue |
| A | GLY625 |
| A | ARG649 |
| A | ARG702 |
| A | HOH912 |
| A | HOH922 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 805 |
| Chain | Residue |
| A | ARG602 |
| A | LYS725 |
| A | GLN726 |
| A | TYR729 |
| A | HOH1043 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 806 |
| Chain | Residue |
| A | LYS725 |
| A | TYR729 |
| A | HOH1038 |
| A | HOH1041 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 29 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGKVFlAechnllpeqdkml.....VAVK |
| Chain | Residue | Details |
| A | LEU516-LYS544 | |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLATRNCLV |
| Chain | Residue | Details |
| A | PHE646-VAL658 | |
| site_id | PS00239 |
| Number of Residues | 9 |
| Details | RECEPTOR_TYR_KIN_II Receptor tyrosine kinase class II signature. DIYstdYYR |
| Chain | Residue | Details |
| A | ASP674-ARG682 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Motif: {"description":"DXXLL","evidences":[{"source":"PubMed","id":"26446845","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"8155326","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"15488758","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8155326","evidenceCode":"ECO:0000269"}]} |
