4PLN
Crystal Structure of Chicken Netrin-1 (LN-LE3) complexed with mouse Neogenin (FN4-5)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| C | 0005887 | cellular_component | integral component of plasma membrane |
| C | 0007399 | biological_process | nervous system development |
| C | 0007411 | biological_process | axon guidance |
| C | 0030513 | biological_process | positive regulation of BMP signaling pathway |
| C | 0038023 | molecular_function | signaling receptor activity |
| C | 0055072 | biological_process | iron ion homeostasis |
| D | 0005887 | cellular_component | integral component of plasma membrane |
| D | 0007399 | biological_process | nervous system development |
| D | 0007411 | biological_process | axon guidance |
| D | 0030513 | biological_process | positive regulation of BMP signaling pathway |
| D | 0038023 | molecular_function | signaling receptor activity |
| D | 0055072 | biological_process | iron ion homeostasis |
Functional Information from PROSITE/UniProt
| site_id | PS00022 |
| Number of Residues | 12 |
| Details | EGF_1 EGF-like domain signature 1. CdCkhNtaGPeC |
| Chain | Residue | Details |
| A | CYS306-CYS317 | |
| A | CYS425-CYS436 |
| site_id | PS01248 |
| Number of Residues | 35 |
| Details | EGF_LAM_1 Laminin-type EGF-like (LE) domain signature. Cd.CkhntaGpeCdrCkpfhYdrpwqratareane.C |
| Chain | Residue | Details |
| A | CYS306-CYS340 | |
| A | CYS370-CYS406 | |
| A | CYS425-CYS453 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 474 |
| Details | Domain: {"description":"Laminin N-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00466","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 110 |
| Details | Domain: {"description":"Laminin EGF-like 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00460","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 124 |
| Details | Domain: {"description":"Laminin EGF-like 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00460","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 98 |
| Details | Domain: {"description":"Laminin EGF-like 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00460","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 180 |
| Details | Domain: {"description":"Fibronectin type-III 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
