4PLH
Crystal structure of ancestral apicomplexan malate dehydrogenase with oxamate.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| A | 0006089 | biological_process | lactate metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| B | 0006089 | biological_process | lactate metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| C | 0006089 | biological_process | lactate metabolic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0019752 | biological_process | carboxylic acid metabolic process |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| D | 0006089 | biological_process | lactate metabolic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue OXM A 401 |
| Chain | Residue |
| A | ASN122 |
| A | ARG153 |
| A | HIS177 |
| A | GLY220 |
| A | NAI403 |
| A | HOH520 |
| A | HOH596 |
| A | HOH609 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 402 |
| Chain | Residue |
| A | ILE15 |
| A | GLY16 |
| A | THR79 |
| A | NAI403 |
| A | GLY13 |
| site_id | AC3 |
| Number of Residues | 29 |
| Details | binding site for residue NAI A 403 |
| Chain | Residue |
| A | GLY13 |
| A | ASN14 |
| A | ILE15 |
| A | PHE34 |
| A | ASP35 |
| A | ILE36 |
| A | VAL37 |
| A | MET40 |
| A | THR79 |
| A | ALA80 |
| A | GLY81 |
| A | ILE100 |
| A | VAL120 |
| A | ASN122 |
| A | MET145 |
| A | LEU149 |
| A | HIS177 |
| A | OXM401 |
| A | NA402 |
| A | HOH502 |
| A | HOH518 |
| A | HOH536 |
| A | HOH538 |
| A | HOH539 |
| A | HOH540 |
| A | HOH542 |
| A | HOH560 |
| A | HOH573 |
| D | GLY87 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue OXM B 401 |
| Chain | Residue |
| B | ASN122 |
| B | ARG153 |
| B | HIS177 |
| B | GLY220 |
| B | NAI402 |
| B | HOH528 |
| site_id | AC5 |
| Number of Residues | 31 |
| Details | binding site for residue NAI B 402 |
| Chain | Residue |
| B | GLY13 |
| B | ASN14 |
| B | ILE15 |
| B | PHE34 |
| B | ASP35 |
| B | ILE36 |
| B | VAL37 |
| B | MET40 |
| B | THR79 |
| B | ALA80 |
| B | GLY81 |
| B | ILE82 |
| B | PRO83 |
| B | ILE100 |
| B | VAL120 |
| B | ASN122 |
| B | MET145 |
| B | LEU149 |
| B | HIS177 |
| B | ALA232 |
| B | OXM401 |
| B | HOH508 |
| B | HOH509 |
| B | HOH512 |
| B | HOH523 |
| B | HOH526 |
| B | HOH544 |
| B | HOH545 |
| B | HOH546 |
| B | HOH548 |
| B | HOH562 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue OXM C 401 |
| Chain | Residue |
| C | ASN122 |
| C | ARG153 |
| C | HIS177 |
| C | GLY220 |
| C | NAI402 |
| C | HOH587 |
| site_id | AC7 |
| Number of Residues | 22 |
| Details | binding site for residue NAI C 402 |
| Chain | Residue |
| C | LEU149 |
| C | HIS177 |
| C | OXM401 |
| C | HOH517 |
| C | HOH518 |
| C | HOH533 |
| C | HOH548 |
| C | HOH571 |
| C | GLY13 |
| C | ASN14 |
| C | ILE15 |
| C | ASP35 |
| C | ILE36 |
| C | VAL37 |
| C | MET40 |
| C | THR79 |
| C | ALA80 |
| C | GLY81 |
| C | ILE100 |
| C | VAL120 |
| C | ASN122 |
| C | MET145 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue OXM D 401 |
| Chain | Residue |
| D | ASN122 |
| D | ARG153 |
| D | HIS177 |
| D | GLY220 |
| D | NAI403 |
| D | HOH529 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue NA D 402 |
| Chain | Residue |
| D | GLY13 |
| D | GLY16 |
| D | THR79 |
| D | NAI403 |
| site_id | AD1 |
| Number of Residues | 26 |
| Details | binding site for residue NAI D 403 |
| Chain | Residue |
| D | GLY13 |
| D | ASN14 |
| D | ILE15 |
| D | ASP35 |
| D | ILE36 |
| D | VAL37 |
| D | MET40 |
| D | THR79 |
| D | ALA80 |
| D | GLY81 |
| D | ILE100 |
| D | VAL120 |
| D | ASN122 |
| D | MET145 |
| D | LEU149 |
| D | HIS177 |
| D | OXM401 |
| D | NA402 |
| D | HOH525 |
| D | HOH544 |
| D | HOH545 |
| D | HOH561 |
| D | HOH569 |
| D | HOH596 |
| D | HOH610 |
| D | HOH633 |
