4PLG
Crystal structure of ancestral apicomplexan lactate dehydrogenase with oxamate.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| A | 0006089 | biological_process | lactate metabolic process |
| A | 0006090 | biological_process | pyruvate metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| B | 0006089 | biological_process | lactate metabolic process |
| B | 0006090 | biological_process | pyruvate metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue OXM A 401 |
| Chain | Residue |
| A | ARG99 |
| A | ASN131 |
| A | ARG162 |
| A | HIS186 |
| A | GLY229 |
| A | NA406 |
| A | NAI409 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 402 |
| Chain | Residue |
| A | GLY20 |
| A | THR83 |
| A | NAI409 |
| A | GLY17 |
| A | ILE19 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 403 |
| Chain | Residue |
| A | LEU13 |
| A | ILE14 |
| A | GLY15 |
| A | MET23 |
| A | ILE81 |
| A | THR83 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue NA A 404 |
| Chain | Residue |
| A | MET154 |
| A | ALA155 |
| A | GLY156 |
| A | VAL157 |
| A | MET252 |
| A | VAL265 |
| A | CYS266 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue NA A 405 |
| Chain | Residue |
| A | GLY156 |
| A | VAL182 |
| A | ILE183 |
| A | GLY184 |
| A | VAL265 |
| A | GLY282 |
| A | HOH639 |
| A | HOH668 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 406 |
| Chain | Residue |
| A | GLY229 |
| A | SER240 |
| A | ALA241 |
| A | OXM401 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 407 |
| Chain | Residue |
| A | ASP159 |
| A | ARG162 |
| A | MET190 |
| A | THR225 |
| A | NA408 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 408 |
| Chain | Residue |
| A | ARG99 |
| A | THR225 |
| A | LYS226 |
| A | ALA228 |
| A | GLY229 |
| A | NA407 |
| site_id | AC9 |
| Number of Residues | 31 |
| Details | binding site for residue NAI A 409 |
| Chain | Residue |
| A | GLY17 |
| A | MET18 |
| A | ILE19 |
| A | PHE38 |
| A | ASP39 |
| A | VAL40 |
| A | VAL41 |
| A | MET44 |
| A | THR83 |
| A | ALA84 |
| A | GLY85 |
| A | LEU86 |
| A | THR87 |
| A | ASN106 |
| A | ILE109 |
| A | ILE129 |
| A | ASN131 |
| A | MET154 |
| A | LEU158 |
| A | HIS186 |
| A | ALA241 |
| A | PRO245 |
| A | OXM401 |
| A | NA402 |
| A | HOH636 |
| A | HOH637 |
| A | HOH643 |
| A | HOH656 |
| A | HOH698 |
| A | HOH699 |
| A | HOH710 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue OXM B 401 |
| Chain | Residue |
| B | TRP97 |
| B | ARG99 |
| B | ASN131 |
| B | ARG162 |
| B | HIS186 |
| B | GLY229 |
| B | NAI403 |
| B | HOH629 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue NA B 402 |
| Chain | Residue |
| B | PRO122 |
| B | ASN123 |
| B | ALA124 |
| B | LEU146 |
| B | LYS150 |
| site_id | AD3 |
| Number of Residues | 32 |
| Details | binding site for residue NAI B 403 |
| Chain | Residue |
| B | MET44 |
| B | TYR71 |
| B | THR83 |
| B | ALA84 |
| B | GLY85 |
| B | LEU86 |
| B | THR87 |
| B | LEU102 |
| B | ASN106 |
| B | ILE109 |
| B | ILE129 |
| B | ASN131 |
| B | MET154 |
| B | LEU158 |
| B | HIS186 |
| B | PRO245 |
| B | OXM401 |
| B | HOH608 |
| B | HOH639 |
| B | HOH690 |
| B | HOH698 |
| B | HOH727 |
| B | HOH743 |
| B | HOH791 |
| B | HOH803 |
| B | GLY17 |
| B | MET18 |
| B | ILE19 |
| B | PHE38 |
| B | ASP39 |
| B | VAL40 |
| B | VAL41 |
