4PLF
Crystal structure of ancestral apicomplexan lactate dehydrogenase with lactate.
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0003824 | molecular_function | catalytic activity |
A | 0004459 | molecular_function | L-lactate dehydrogenase activity |
A | 0006089 | biological_process | lactate metabolic process |
A | 0006090 | biological_process | pyruvate metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0019752 | biological_process | carboxylic acid metabolic process |
B | 0000166 | molecular_function | nucleotide binding |
B | 0003824 | molecular_function | catalytic activity |
B | 0004459 | molecular_function | L-lactate dehydrogenase activity |
B | 0006089 | biological_process | lactate metabolic process |
B | 0006090 | biological_process | pyruvate metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
B | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 35 |
Details | binding site for residue NAI A 401 |
Chain | Residue |
A | GLY17 |
A | ALA84 |
A | GLY85 |
A | LEU86 |
A | THR87 |
A | ASN106 |
A | ILE109 |
A | ILE129 |
A | ASN131 |
A | MET154 |
A | LEU158 |
A | MET18 |
A | HIS186 |
A | ALA241 |
A | PRO245 |
A | PYR402 |
A | HOH531 |
A | HOH536 |
A | HOH675 |
A | HOH682 |
A | HOH690 |
A | HOH694 |
A | ILE19 |
A | HOH755 |
A | HOH766 |
A | HOH818 |
A | HOH836 |
A | HOH917 |
A | HOH1054 |
A | PHE38 |
A | ASP39 |
A | VAL40 |
A | VAL41 |
A | MET44 |
A | THR83 |
site_id | AC2 |
Number of Residues | 7 |
Details | binding site for residue PYR A 402 |
Chain | Residue |
A | ARG99 |
A | ASN131 |
A | ARG162 |
A | HIS186 |
A | GLY229 |
A | NAI401 |
A | HOH680 |
site_id | AC3 |
Number of Residues | 34 |
Details | binding site for residue NAD B 401 |
Chain | Residue |
B | GLY17 |
B | MET18 |
B | ILE19 |
B | PHE38 |
B | ASP39 |
B | VAL40 |
B | VAL41 |
B | TYR71 |
B | THR83 |
B | ALA84 |
B | GLY85 |
B | LEU86 |
B | THR87 |
B | LEU102 |
B | ASN106 |
B | ILE109 |
B | ILE129 |
B | THR130 |
B | ASN131 |
B | MET154 |
B | LEU158 |
B | HIS186 |
B | PYR402 |
B | HOH633 |
B | HOH672 |
B | HOH707 |
B | HOH721 |
B | HOH737 |
B | HOH744 |
B | HOH751 |
B | HOH775 |
B | HOH798 |
B | HOH828 |
B | HOH931 |
site_id | AC4 |
Number of Residues | 8 |
Details | binding site for residue PYR B 402 |
Chain | Residue |
B | TRP97 |
B | ARG99 |
B | ASN131 |
B | ARG162 |
B | HIS186 |
B | GLY229 |
B | NAD401 |
B | HOH653 |