4PLF
Crystal structure of ancestral apicomplexan lactate dehydrogenase with lactate.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| A | 0006089 | biological_process | lactate metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| B | 0006089 | biological_process | lactate metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 35 |
| Details | binding site for residue NAI A 401 |
| Chain | Residue |
| A | GLY17 |
| A | ALA84 |
| A | GLY85 |
| A | LEU86 |
| A | THR87 |
| A | ASN106 |
| A | ILE109 |
| A | ILE129 |
| A | ASN131 |
| A | MET154 |
| A | LEU158 |
| A | MET18 |
| A | HIS186 |
| A | ALA241 |
| A | PRO245 |
| A | PYR402 |
| A | HOH531 |
| A | HOH536 |
| A | HOH675 |
| A | HOH682 |
| A | HOH690 |
| A | HOH694 |
| A | ILE19 |
| A | HOH755 |
| A | HOH766 |
| A | HOH818 |
| A | HOH836 |
| A | HOH917 |
| A | HOH1054 |
| A | PHE38 |
| A | ASP39 |
| A | VAL40 |
| A | VAL41 |
| A | MET44 |
| A | THR83 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue PYR A 402 |
| Chain | Residue |
| A | ARG99 |
| A | ASN131 |
| A | ARG162 |
| A | HIS186 |
| A | GLY229 |
| A | NAI401 |
| A | HOH680 |
| site_id | AC3 |
| Number of Residues | 34 |
| Details | binding site for residue NAD B 401 |
| Chain | Residue |
| B | GLY17 |
| B | MET18 |
| B | ILE19 |
| B | PHE38 |
| B | ASP39 |
| B | VAL40 |
| B | VAL41 |
| B | TYR71 |
| B | THR83 |
| B | ALA84 |
| B | GLY85 |
| B | LEU86 |
| B | THR87 |
| B | LEU102 |
| B | ASN106 |
| B | ILE109 |
| B | ILE129 |
| B | THR130 |
| B | ASN131 |
| B | MET154 |
| B | LEU158 |
| B | HIS186 |
| B | PYR402 |
| B | HOH633 |
| B | HOH672 |
| B | HOH707 |
| B | HOH721 |
| B | HOH737 |
| B | HOH744 |
| B | HOH751 |
| B | HOH775 |
| B | HOH798 |
| B | HOH828 |
| B | HOH931 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue PYR B 402 |
| Chain | Residue |
| B | TRP97 |
| B | ARG99 |
| B | ASN131 |
| B | ARG162 |
| B | HIS186 |
| B | GLY229 |
| B | NAD401 |
| B | HOH653 |
