4PLC
Crystal structure of ancestral apicomplexan lactate dehydrogenase with malate.
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0003824 | molecular_function | catalytic activity |
A | 0004459 | molecular_function | L-lactate dehydrogenase activity |
A | 0006089 | biological_process | lactate metabolic process |
A | 0006090 | biological_process | pyruvate metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0019752 | biological_process | carboxylic acid metabolic process |
B | 0000166 | molecular_function | nucleotide binding |
B | 0003824 | molecular_function | catalytic activity |
B | 0004459 | molecular_function | L-lactate dehydrogenase activity |
B | 0006089 | biological_process | lactate metabolic process |
B | 0006090 | biological_process | pyruvate metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
B | 0019752 | biological_process | carboxylic acid metabolic process |
C | 0000166 | molecular_function | nucleotide binding |
C | 0003824 | molecular_function | catalytic activity |
C | 0004459 | molecular_function | L-lactate dehydrogenase activity |
C | 0006089 | biological_process | lactate metabolic process |
C | 0006090 | biological_process | pyruvate metabolic process |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
C | 0019752 | biological_process | carboxylic acid metabolic process |
D | 0000166 | molecular_function | nucleotide binding |
D | 0003824 | molecular_function | catalytic activity |
D | 0004459 | molecular_function | L-lactate dehydrogenase activity |
D | 0006089 | biological_process | lactate metabolic process |
D | 0006090 | biological_process | pyruvate metabolic process |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
D | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 8 |
Details | binding site for residue PYR A 401 |
Chain | Residue |
A | TRP97 |
A | ARG99 |
A | ASN131 |
A | ARG162 |
A | HIS186 |
A | GLY229 |
A | NAI402 |
A | HOH578 |
site_id | AC2 |
Number of Residues | 36 |
Details | binding site for residue NAI A 402 |
Chain | Residue |
A | MET18 |
A | ILE19 |
A | PHE38 |
A | ASP39 |
A | VAL40 |
A | VAL41 |
A | TYR71 |
A | THR83 |
A | ALA84 |
A | GLY85 |
A | LEU86 |
A | THR87 |
A | LEU102 |
A | ASN106 |
A | ILE109 |
A | GLU112 |
A | ILE129 |
A | THR130 |
A | ASN131 |
A | MET154 |
A | LEU158 |
A | HIS186 |
A | ALA241 |
A | PRO245 |
A | PYR401 |
A | HOH546 |
A | HOH549 |
A | HOH558 |
A | HOH592 |
A | HOH643 |
A | HOH664 |
A | HOH676 |
A | HOH681 |
A | HOH751 |
A | HOH826 |
A | GLY17 |
site_id | AC3 |
Number of Residues | 7 |
Details | binding site for residue PYR B 401 |
Chain | Residue |
B | TRP97 |
B | ARG99 |
B | ASN131 |
B | ARG162 |
B | HIS186 |
B | NAD402 |
B | HOH651 |
site_id | AC4 |
Number of Residues | 34 |
Details | binding site for residue NAD B 402 |
Chain | Residue |
B | GLY17 |
B | MET18 |
B | ILE19 |
B | PHE38 |
B | ASP39 |
B | VAL40 |
B | VAL41 |
B | MET44 |
B | TYR71 |
B | THR83 |
B | ALA84 |
B | GLY85 |
B | LEU86 |
B | THR87 |
B | LEU102 |
B | ASN106 |
B | ILE109 |
B | GLU112 |
B | ILE129 |
B | THR130 |
B | ASN131 |
B | MET154 |
B | LEU158 |
B | HIS186 |
B | ALA241 |
B | PYR401 |
B | HOH527 |
B | HOH590 |
B | HOH593 |
B | HOH603 |
B | HOH669 |
B | HOH701 |
B | HOH706 |
B | HOH767 |
site_id | AC5 |
Number of Residues | 8 |
Details | binding site for residue PYR C 401 |
Chain | Residue |
C | TRP97 |
C | ARG99 |
C | ASN131 |
C | ARG162 |
C | HIS186 |
C | GLY229 |
C | NAI402 |
C | HOH545 |
site_id | AC6 |
Number of Residues | 35 |
Details | binding site for residue NAI C 402 |
Chain | Residue |
C | VAL41 |
C | THR83 |
C | ALA84 |
C | GLY85 |
C | LEU86 |
C | THR87 |
C | LEU102 |
C | ASN106 |
C | ILE109 |
C | GLU112 |
C | ILE129 |
C | THR130 |
C | ASN131 |
C | MET154 |
C | LEU158 |
C | HIS186 |
C | ALA241 |
C | PRO245 |
C | PYR401 |
C | HOH551 |
C | HOH556 |
C | HOH559 |
C | HOH635 |
C | HOH636 |
C | HOH640 |
C | HOH741 |
C | HOH764 |
C | HOH767 |
C | HOH840 |
C | GLY17 |
C | MET18 |
C | ILE19 |
C | PHE38 |
C | ASP39 |
C | VAL40 |
site_id | AC7 |
Number of Residues | 8 |
Details | binding site for residue PYR D 401 |
Chain | Residue |
D | TRP97 |
D | ARG99 |
D | ASN131 |
D | ARG162 |
D | HIS186 |
D | GLY229 |
D | NAD402 |
D | HOH624 |
site_id | AC8 |
Number of Residues | 26 |
Details | binding site for residue NAD D 402 |
Chain | Residue |
D | GLY17 |
D | MET18 |
D | ILE19 |
D | PHE38 |
D | ASP39 |
D | VAL40 |
D | VAL41 |
D | MET44 |
D | TYR71 |
D | THR83 |
D | ALA84 |
D | GLY85 |
D | LEU86 |
D | THR87 |
D | ILE129 |
D | ASN131 |
D | MET154 |
D | LEU158 |
D | HIS186 |
D | PYR401 |
D | HOH531 |
D | HOH576 |
D | HOH646 |
D | HOH680 |
D | HOH689 |
D | HOH735 |