4PLC
Crystal structure of ancestral apicomplexan lactate dehydrogenase with malate.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| A | 0006089 | biological_process | lactate metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| B | 0006089 | biological_process | lactate metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| C | 0006089 | biological_process | lactate metabolic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0019752 | biological_process | carboxylic acid metabolic process |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| D | 0006089 | biological_process | lactate metabolic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue PYR A 401 |
| Chain | Residue |
| A | TRP97 |
| A | ARG99 |
| A | ASN131 |
| A | ARG162 |
| A | HIS186 |
| A | GLY229 |
| A | NAI402 |
| A | HOH578 |
| site_id | AC2 |
| Number of Residues | 36 |
| Details | binding site for residue NAI A 402 |
| Chain | Residue |
| A | MET18 |
| A | ILE19 |
| A | PHE38 |
| A | ASP39 |
| A | VAL40 |
| A | VAL41 |
| A | TYR71 |
| A | THR83 |
| A | ALA84 |
| A | GLY85 |
| A | LEU86 |
| A | THR87 |
| A | LEU102 |
| A | ASN106 |
| A | ILE109 |
| A | GLU112 |
| A | ILE129 |
| A | THR130 |
| A | ASN131 |
| A | MET154 |
| A | LEU158 |
| A | HIS186 |
| A | ALA241 |
| A | PRO245 |
| A | PYR401 |
| A | HOH546 |
| A | HOH549 |
| A | HOH558 |
| A | HOH592 |
| A | HOH643 |
| A | HOH664 |
| A | HOH676 |
| A | HOH681 |
| A | HOH751 |
| A | HOH826 |
| A | GLY17 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue PYR B 401 |
| Chain | Residue |
| B | TRP97 |
| B | ARG99 |
| B | ASN131 |
| B | ARG162 |
| B | HIS186 |
| B | NAD402 |
| B | HOH651 |
| site_id | AC4 |
| Number of Residues | 34 |
| Details | binding site for residue NAD B 402 |
| Chain | Residue |
| B | GLY17 |
| B | MET18 |
| B | ILE19 |
| B | PHE38 |
| B | ASP39 |
| B | VAL40 |
| B | VAL41 |
| B | MET44 |
| B | TYR71 |
| B | THR83 |
| B | ALA84 |
| B | GLY85 |
| B | LEU86 |
| B | THR87 |
| B | LEU102 |
| B | ASN106 |
| B | ILE109 |
| B | GLU112 |
| B | ILE129 |
| B | THR130 |
| B | ASN131 |
| B | MET154 |
| B | LEU158 |
| B | HIS186 |
| B | ALA241 |
| B | PYR401 |
| B | HOH527 |
| B | HOH590 |
| B | HOH593 |
| B | HOH603 |
| B | HOH669 |
| B | HOH701 |
| B | HOH706 |
| B | HOH767 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue PYR C 401 |
| Chain | Residue |
| C | TRP97 |
| C | ARG99 |
| C | ASN131 |
| C | ARG162 |
| C | HIS186 |
| C | GLY229 |
| C | NAI402 |
| C | HOH545 |
| site_id | AC6 |
| Number of Residues | 35 |
| Details | binding site for residue NAI C 402 |
| Chain | Residue |
| C | VAL41 |
| C | THR83 |
| C | ALA84 |
| C | GLY85 |
| C | LEU86 |
| C | THR87 |
| C | LEU102 |
| C | ASN106 |
| C | ILE109 |
| C | GLU112 |
| C | ILE129 |
| C | THR130 |
| C | ASN131 |
| C | MET154 |
| C | LEU158 |
| C | HIS186 |
| C | ALA241 |
| C | PRO245 |
| C | PYR401 |
| C | HOH551 |
| C | HOH556 |
| C | HOH559 |
| C | HOH635 |
| C | HOH636 |
| C | HOH640 |
| C | HOH741 |
| C | HOH764 |
| C | HOH767 |
| C | HOH840 |
| C | GLY17 |
| C | MET18 |
| C | ILE19 |
| C | PHE38 |
| C | ASP39 |
| C | VAL40 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue PYR D 401 |
| Chain | Residue |
| D | TRP97 |
| D | ARG99 |
| D | ASN131 |
| D | ARG162 |
| D | HIS186 |
| D | GLY229 |
| D | NAD402 |
| D | HOH624 |
| site_id | AC8 |
| Number of Residues | 26 |
| Details | binding site for residue NAD D 402 |
| Chain | Residue |
| D | GLY17 |
| D | MET18 |
| D | ILE19 |
| D | PHE38 |
| D | ASP39 |
| D | VAL40 |
| D | VAL41 |
| D | MET44 |
| D | TYR71 |
| D | THR83 |
| D | ALA84 |
| D | GLY85 |
| D | LEU86 |
| D | THR87 |
| D | ILE129 |
| D | ASN131 |
| D | MET154 |
| D | LEU158 |
| D | HIS186 |
| D | PYR401 |
| D | HOH531 |
| D | HOH576 |
| D | HOH646 |
| D | HOH680 |
| D | HOH689 |
| D | HOH735 |
