Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008237 | molecular_function | metallopeptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 801 |
| Chain | Residue |
| A | HIS686 |
| A | HIS690 |
| A | GLU735 |
| A | GM6802 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | binding site for residue GM6 A 802 |
| Chain | Residue |
| A | LYS656 |
| A | GLY657 |
| A | LYS673 |
| A | GLY674 |
| A | VAL675 |
| A | LEU677 |
| A | HIS686 |
| A | GLU687 |
| A | HIS690 |
| A | TYR728 |
| A | GLU735 |
| A | ZN801 |
| A | GOL804 |
| A | ASP328 |
| A | PHE329 |
| A | VAL653 |
| A | HIS654 |
| A | SER655 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 803 |
| Chain | Residue |
| A | PHE718 |
| A | LYS719 |
| A | SER723 |
| A | ARG730 |
| A | HOH943 |
| A | HOH973 |
| A | HOH974 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 804 |
| Chain | Residue |
| A | LEU658 |
| A | TYR659 |
| A | HIS690 |
| A | GLU735 |
| A | GM6802 |
| A | HOH1247 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 805 |
| Chain | Residue |
| A | LYS295 |
| A | GLN411 |
| A | ASP495 |
| A | HOH920 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 806 |
| Chain | Residue |
| A | PRO661 |
| A | ARG664 |
| A | SER705 |
| A | HOH1232 |
| A | HOH1272 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. GFIHEFGHAV |
| Chain | Residue | Details |
| A | GLY683-VAL692 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | GLU687 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000269|PubMed:11700563, ECO:0000269|PubMed:14718924, ECO:0000269|PubMed:14718925, ECO:0000269|PubMed:15911756, ECO:0000269|PubMed:22342144, ECO:0000269|PubMed:25372673, ECO:0000269|PubMed:26492514, ECO:0000269|PubMed:26578066, ECO:0007744|PDB:1J7N, ECO:0007744|PDB:1PWP, ECO:0007744|PDB:1PWQ, ECO:0007744|PDB:1PWU, ECO:0007744|PDB:1PWW, ECO:0007744|PDB:1YQY, ECO:0007744|PDB:4DV8, ECO:0007744|PDB:4PKQ, ECO:0007744|PDB:4PKR, ECO:0007744|PDB:4PKS, ECO:0007744|PDB:4PKT, ECO:0007744|PDB:4PKV, ECO:0007744|PDB:4PKW, ECO:0007744|PDB:4WF6, ECO:0007744|PDB:4XM6, ECO:0007744|PDB:4XM7, ECO:0007744|PDB:5D1S, ECO:0007744|PDB:5D1T |
| Chain | Residue | Details |
| A | HIS686 | |
| A | HIS690 | |
| A | GLU735 | |
| Chain | Residue | Details |
| A | TYR728 | |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 641 |
| Chain | Residue | Details |
| A | HIS686 | metal ligand |
| A | GLU687 | proton acceptor, proton donor |
| A | HIS690 | metal ligand |
| A | TYR728 | electrostatic stabiliser |
| A | GLU735 | metal ligand |
