Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0008237 | molecular_function | metallopeptidase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 15 |
Details | binding site for residue 2ZL A 801 |
Chain | Residue |
A | ASP328 |
A | GLU735 |
A | GLU739 |
A | ARG742 |
A | ZN802 |
A | GOL804 |
A | HOH1179 |
A | SER655 |
A | LYS656 |
A | GLY657 |
A | LEU677 |
A | HIS686 |
A | GLU687 |
A | HIS690 |
A | TYR728 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue ZN A 802 |
Chain | Residue |
A | HIS686 |
A | HIS690 |
A | GLU735 |
A | 2ZL801 |
A | GOL804 |
site_id | AC3 |
Number of Residues | 2 |
Details | binding site for residue CL A 803 |
Chain | Residue |
A | ARG502 |
A | ARG544 |
site_id | AC4 |
Number of Residues | 7 |
Details | binding site for residue GOL A 804 |
Chain | Residue |
A | LEU658 |
A | TYR659 |
A | HIS690 |
A | GLU735 |
A | 2ZL801 |
A | ZN802 |
A | HOH1208 |
Functional Information from PROSITE/UniProt
site_id | PS00142 |
Number of Residues | 10 |
Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. GFIHEFGHAV |
Chain | Residue | Details |
A | GLY683-VAL692 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | GLU687 | |
site_id | SWS_FT_FI2 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000269|PubMed:11700563, ECO:0000269|PubMed:14718924, ECO:0000269|PubMed:14718925, ECO:0000269|PubMed:15911756, ECO:0000269|PubMed:22342144, ECO:0000269|PubMed:25372673, ECO:0000269|PubMed:26492514, ECO:0000269|PubMed:26578066, ECO:0007744|PDB:1J7N, ECO:0007744|PDB:1PWP, ECO:0007744|PDB:1PWQ, ECO:0007744|PDB:1PWU, ECO:0007744|PDB:1PWW, ECO:0007744|PDB:1YQY, ECO:0007744|PDB:4DV8, ECO:0007744|PDB:4PKQ, ECO:0007744|PDB:4PKR, ECO:0007744|PDB:4PKS, ECO:0007744|PDB:4PKT, ECO:0007744|PDB:4PKV, ECO:0007744|PDB:4PKW, ECO:0007744|PDB:4WF6, ECO:0007744|PDB:4XM6, ECO:0007744|PDB:4XM7, ECO:0007744|PDB:5D1S, ECO:0007744|PDB:5D1T |
Chain | Residue | Details |
A | HIS686 | |
A | HIS690 | |
A | GLU735 | |
Chain | Residue | Details |
A | TYR728 | |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 641 |
Chain | Residue | Details |
A | HIS686 | metal ligand |
A | GLU687 | proton acceptor, proton donor |
A | HIS690 | metal ligand |
A | TYR728 | electrostatic stabiliser |
A | GLU735 | metal ligand |