4PKQ
Anthrax toxin lethal factor with bound zinc
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008237 | molecular_function | metallopeptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 801 |
| Chain | Residue |
| A | HIS686 |
| A | HIS690 |
| A | GLU735 |
| A | HOH1046 |
| A | HOH1048 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue PGE A 802 |
| Chain | Residue |
| A | GLN522 |
| A | ARG523 |
| A | ASN524 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 803 |
| Chain | Residue |
| A | LYS434 |
| A | ILE435 |
| A | TYR436 |
| A | ASN433 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. GFIHEFGHAV |
| Chain | Residue | Details |
| A | GLY683-VAL692 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000269|PubMed:19651869, ECO:0000269|PubMed:9573135 |
| Chain | Residue | Details |
| A | GLU687 |
| Chain | Residue | Details |
| A | HIS686 | |
| A | HIS690 | |
| A | GLU735 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01339 |
| Chain | Residue | Details |
| A | TYR728 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 641 |
| Chain | Residue | Details |
| A | HIS686 | metal ligand |
| A | GLU687 | proton acceptor, proton donor |
| A | HIS690 | metal ligand |
| A | TYR728 | electrostatic stabiliser |
| A | GLU735 | metal ligand |
