4PK2

tubulin acetyltransferase complex with bisubstrate analog

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005874	cellular_component	microtubule
A	0019799	molecular_function	tubulin N-acetyltransferase activity
A	0071929	biological_process	alpha-tubulin acetylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	47
Details	binding site for B 1 to 7, bisubstrate analog

Chain	Residue
A	GLN58
A	PHE124
A	TYR125
A	ILE126
A	GLN131
A	ARG132
A	HIS133
A	GLY134
A	GLY136
A	ARG137
A	ASP157
A	ILE64
A	ARG158
A	SER160
A	LYS162
A	LEU163
A	LYS165
A	PHE166
A	LYS169
A	HIS170
A	ASN182
A	PHE183
A	SER83
A	HOH303
A	HOH323
A	HOH332
A	HOH340
A	HOH358
A	HOH379
A	HOH386
A	HOH393
A	HOH395
A	HOH396
A	SER84
A	HOH521
A	HOH525
A	HOH547
B	HOH101
B	HOH102
B	HOH103
B	HOH105
B	HOH106
A	ALA85
A	ARG86
A	LYS102
A	LEU122
A	ASP123

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03130, ECO:0000269|PubMed:23071314, ECO:0000269|PubMed:23071318, ECO:0000269|PubMed:24906155

Chain	Residue	Details
A	PHE124
A	SER160

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Crucial for catalytic activity => ECO:0000255|HAMAP-Rule:MF_03130, ECO:0000269|PubMed:23071318

Chain	Residue	Details
A	GLN58

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000250|UniProtKB:Q8K341, ECO:0000255|HAMAP-Rule:MF_03130

Chain	Residue	Details
A	LYS56
A	LYS146

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