4PIG

Crystal structure of the ubiquitin K11S mutant

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue CA A 101

Chain	Residue
A	HOH206
B	HOH204
B	HOH213
D	THR12
D	HOH207
D	HOH215
D	HOH224

---

site_id	AC2
Number of Residues	2
Details	binding site for residue CL A 102

Chain	Residue
A	LEU71
C	LEU71

---

site_id	AC3
Number of Residues	2
Details	binding site for residue CL A 103

Chain	Residue
A	LEU15
A	GLU16

---

site_id	AC4
Number of Residues	3
Details	binding site for residue CA B 101

Chain	Residue
B	ASN60
B	HOH212
B	HOH217

---

site_id	AC5
Number of Residues	3
Details	binding site for residue NA B 102

Chain	Residue
B	TYR59
D	GLU18
D	HOH222

---

site_id	AC6
Number of Residues	3
Details	binding site for residue CL C 101

Chain	Residue
C	LEU15
C	GLU16
C	HOH245

---

site_id	AC7
Number of Residues	3
Details	binding site for residue CL C 102

Chain	Residue
B	HIS68
C	GLN49
C	HOH226

---

site_id	AC8
Number of Residues	3
Details	binding site for residue CL C 103

Chain	Residue
C	HIS68
D	LYS6
D	HIS68

---

site_id	AC9
Number of Residues	5
Details	binding site for residue CA D 101

Chain	Residue
A	GLU24
A	HOH225
A	HOH227
D	ASP32
D	HOH203

---

site_id	AD1
Number of Residues	3
Details	binding site for residue CA D 102

Chain	Residue
D	GLU24
D	ASP52
D	HOH256

---

site_id	AD2
Number of Residues	3
Details	binding site for residue CL D 103

Chain	Residue
B	LEU71
D	LEU71
D	HOH227

---

site_id	AD3
Number of Residues	4
Details	binding site for residue CL D 104

Chain	Residue
D	LEU15
D	GLU16
D	HOH235
D	HOH244

---

site_id	AD4
Number of Residues	3
Details	binding site for residue CL D 105

Chain	Residue
D	ARG42
D	ARG72
D	HOH229

---

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
A	LYS27-ASP52

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	SITE: Interacts with activating enzyme

Chain	Residue	Details
A	ARG54
A	ARG72
B	ARG54
B	ARG72
C	ARG54
C	ARG72
D	ARG54
D	ARG72

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	SITE: Essential for function

Chain	Residue	Details
A	HIS68
B	HIS68
C	HIS68
D	HIS68

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25474007, ECO:0000269|PubMed:25527291

Chain	Residue	Details
A	SER65
B	SER65
C	SER65
D	SER65

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457

Chain	Residue	Details
A	THR66
B	THR66
C	THR66
D	THR66

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: ADP-ribosylglycine => ECO:0000269|PubMed:28525742

Chain	Residue	Details
A	GLY76
B	GLY76
C	GLY76
D	GLY76

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603

Chain	Residue	Details
A	LYS6
B	LYS6
C	LYS6
D	LYS6

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)

Chain	Residue	Details
A	GLY76
B	GLY76
C	GLY76
D	GLY76

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144

Chain	Residue	Details
A	SER11
A	LYS48
B	SER11
B	LYS48
C	SER11
C	LYS48
D	SER11
D	LYS48

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860

Chain	Residue	Details
A	LYS27
B	LYS27
C	LYS27
D	LYS27

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127

Chain	Residue	Details
A	LYS29
B	LYS29
C	LYS29
D	LYS29

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577

Chain	Residue	Details
A	LYS33
B	LYS33
C	LYS33
D	LYS33

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106

Chain	Residue	Details
A	LYS63
B	LYS63
C	LYS63
D	LYS63

---