4PHI
Crystal structure of HEWL with hexatungstotellurate(VI)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003796 | molecular_function | lysozyme activity |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0016231 | molecular_function | beta-N-acetylglucosaminidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0016998 | biological_process | cell wall macromolecule catabolic process |
| A | 0031640 | biological_process | killing of cells of another organism |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0050829 | biological_process | defense response to Gram-negative bacterium |
| A | 0050830 | biological_process | defense response to Gram-positive bacterium |
| A | 0051672 | biological_process | obsolete catabolism by organism of cell wall peptidoglycan in other organism |
| B | 0003796 | molecular_function | lysozyme activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0016231 | molecular_function | beta-N-acetylglucosaminidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| B | 0016998 | biological_process | cell wall macromolecule catabolic process |
| B | 0031640 | biological_process | killing of cells of another organism |
| B | 0042742 | biological_process | defense response to bacterium |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0050829 | biological_process | defense response to Gram-negative bacterium |
| B | 0050830 | biological_process | defense response to Gram-positive bacterium |
| B | 0051672 | biological_process | obsolete catabolism by organism of cell wall peptidoglycan in other organism |
| C | 0003796 | molecular_function | lysozyme activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005615 | cellular_component | extracellular space |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005783 | cellular_component | endoplasmic reticulum |
| C | 0016231 | molecular_function | beta-N-acetylglucosaminidase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| C | 0016998 | biological_process | cell wall macromolecule catabolic process |
| C | 0031640 | biological_process | killing of cells of another organism |
| C | 0042742 | biological_process | defense response to bacterium |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0050829 | biological_process | defense response to Gram-negative bacterium |
| C | 0050830 | biological_process | defense response to Gram-positive bacterium |
| C | 0051672 | biological_process | obsolete catabolism by organism of cell wall peptidoglycan in other organism |
| D | 0003796 | molecular_function | lysozyme activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005615 | cellular_component | extracellular space |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005783 | cellular_component | endoplasmic reticulum |
| D | 0016231 | molecular_function | beta-N-acetylglucosaminidase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| D | 0016998 | biological_process | cell wall macromolecule catabolic process |
| D | 0031640 | biological_process | killing of cells of another organism |
| D | 0042742 | biological_process | defense response to bacterium |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0050829 | biological_process | defense response to Gram-negative bacterium |
| D | 0050830 | biological_process | defense response to Gram-positive bacterium |
| D | 0051672 | biological_process | obsolete catabolism by organism of cell wall peptidoglycan in other organism |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue TEW A 201 |
| Chain | Residue |
| A | ASN65 |
| A | HOH428 |
| A | HOH443 |
| A | HOH471 |
| B | GLY4 |
| B | ARG5 |
| B | CYS6 |
| D | LYS1 |
| D | VAL2 |
| D | GLN41 |
| A | ASN74 |
| A | ILE78 |
| A | PRO79 |
| A | HOH321 |
| A | HOH368 |
| A | HOH409 |
| A | HOH419 |
| A | HOH424 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue TEW A 202 |
| Chain | Residue |
| A | ARG125 |
| A | GLY126 |
| A | CYS127 |
| A | HOH302 |
| A | HOH310 |
| A | HOH418 |
| A | HOH463 |
| B | ASN113 |
| C | ARG125 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue NA A 203 |
| Chain | Residue |
| A | ILE88 |
| A | HOH464 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue GOL A 204 |
| Chain | Residue |
| A | GLY71 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue ACT A 205 |
| Chain | Residue |
| A | TRP62 |
| A | ARG73 |
| A | HOH451 |
| site_id | AC6 |
| Number of Residues | 20 |
| Details | binding site for residue TEW B 201 |
| Chain | Residue |
| B | LYS1 |
| B | VAL2 |
| B | GLN41 |
| B | SER86 |
| B | HOH306 |
| B | HOH322 |
| B | HOH325 |
| B | HOH342 |
| B | HOH394 |
| B | HOH409 |
| B | HOH424 |
| B | HOH434 |
| B | HOH438 |
| B | HOH440 |
| B | HOH451 |
| B | HOH462 |
| B | HOH467 |
| C | ASN65 |
| C | PRO79 |
| D | ARG5 |
| site_id | AC7 |
| Number of Residues | 17 |
| Details | binding site for residue TEW B 202 |
| Chain | Residue |
| B | ARG45 |
| B | THR47 |
| B | GLY49 |
| B | ARG68 |
| B | HOH316 |
| B | HOH344 |
| B | HOH347 |
| B | HOH420 |
| B | HOH422 |
| B | HOH431 |
| B | HOH437 |
| B | HOH456 |
| C | HOH403 |
| D | ARG73 |
| D | ASN74 |
| D | LEU75 |
| D | HOH306 |
| site_id | AC8 |
| Number of Residues | 19 |
| Details | binding site for residue TEW B 203 |
| Chain | Residue |
| B | ASN65 |
| B | ASN74 |
| B | ILE78 |
| B | PRO79 |
| B | HOH304 |
| B | HOH309 |
| B | HOH310 |
| B | HOH311 |
| B | HOH326 |
| B | HOH400 |
| B | HOH404 |
| B | HOH408 |
| B | HOH428 |
| C | LYS1 |
| C | VAL2 |
| C | GLN41 |
| D | TEW201 |
| D | HOH301 |
| D | HOH304 |
| site_id | AC9 |
| Number of Residues | 13 |
| Details | binding site for residue TEW B 204 |
| Chain | Residue |
| B | HOH433 |
| D | ASN106 |
| D | LYS116 |
| A | ARG112 |
| A | LYS116 |
| B | ARG73 |
| B | LYS116 |
| B | GLY117 |
| B | TEW205 |
| B | HOH307 |
| B | HOH308 |
| B | HOH318 |
| B | HOH330 |
| site_id | AD1 |
| Number of Residues | 15 |
| Details | binding site for residue TEW B 205 |
| Chain | Residue |
| A | GLY4 |
| A | ARG5 |
| A | CYS6 |
| A | GLU7 |
| B | ARG73 |
| B | ASN74 |
| B | LEU75 |
| B | ASN77 |
| B | LYS97 |
| B | TEW204 |
| B | HOH302 |
| B | HOH318 |
| B | HOH327 |
| B | HOH329 |
| B | HOH436 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue NA B 206 |
| Chain | Residue |
| B | HOH453 |
| C | ARG45 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue NA B 207 |
| Chain | Residue |
| B | ASN59 |
| B | TRP63 |
| B | HOH358 |
| B | HOH439 |
| B | HOH468 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue NA C 201 |
| Chain | Residue |
| A | HOH363 |
| C | HOH424 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue NA C 202 |
| Chain | Residue |
| C | ASP87 |
| C | ILE88 |
| C | HOH417 |
| C | HOH418 |
| site_id | AD6 |
| Number of Residues | 22 |
| Details | binding site for residue TEW D 201 |
| Chain | Residue |
| A | LYS1 |
| A | VAL2 |
| A | GLN41 |
| B | TEW203 |
| B | HOH310 |
| D | ASN65 |
| D | ASN74 |
| D | ILE78 |
| D | PRO79 |
| D | HOH301 |
| D | HOH302 |
| D | HOH303 |
| D | HOH304 |
| D | HOH307 |
| D | HOH309 |
| D | HOH311 |
| D | HOH317 |
| D | HOH340 |
| D | HOH370 |
| D | HOH377 |
| D | HOH401 |
| D | HOH437 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue NA D 202 |
| Chain | Residue |
| B | HOH338 |
| D | GLU7 |
| D | ARG14 |
| D | HOH328 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue ACT D 203 |
| Chain | Residue |
| D | ASN59 |
| D | TRP63 |
| D | ALA107 |
| D | TRP108 |
Functional Information from PROSITE/UniProt
| site_id | PS00128 |
| Number of Residues | 19 |
| Details | GLYCOSYL_HYDROL_F22_1 Glycosyl hydrolases family 22 (GH22) domain signature. CnipCsaLlssDItasvnC |
| Chain | Residue | Details |
| A | CYS76-CYS94 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | ACT_SITE: |
| Chain | Residue | Details |
| A | GLU35 | |
| A | ASP52 | |
| B | GLU35 | |
| B | ASP52 | |
| C | GLU35 | |
| C | ASP52 | |
| D | GLU35 | |
| D | ASP52 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ASP101 | |
| B | ASP101 | |
| C | ASP101 | |
| D | ASP101 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 203 |
| Chain | Residue | Details |
| A | GLU35 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | ASN46 | |
| A | ASP48 | |
| A | SER50 | |
| A | ASP52 | covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, polar/non-polar interaction |
| A | ASN59 |
| site_id | MCSA2 |
| Number of Residues | 6 |
| Details | M-CSA 203 |
| Chain | Residue | Details |
| B | GLU35 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | ASN46 | |
| B | ASP48 | |
| B | SER50 | |
| B | ASP52 | covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, polar/non-polar interaction |
| B | ASN59 |
| site_id | MCSA3 |
| Number of Residues | 6 |
| Details | M-CSA 203 |
| Chain | Residue | Details |
| C | GLU35 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| C | ASN46 | |
| C | ASP48 | |
| C | SER50 | |
| C | ASP52 | covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, polar/non-polar interaction |
| C | ASN59 |
| site_id | MCSA4 |
| Number of Residues | 6 |
| Details | M-CSA 203 |
| Chain | Residue | Details |
| D | GLU35 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| D | ASN46 | |
| D | ASP48 | |
| D | SER50 | |
| D | ASP52 | covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, polar/non-polar interaction |
| D | ASN59 |
