Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004013 | molecular_function | adenosylhomocysteinase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0005783 | cellular_component | endoplasmic reticulum |
A | 0005829 | cellular_component | cytosol |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0016787 | molecular_function | hydrolase activity |
A | 0033353 | biological_process | S-adenosylmethionine cycle |
A | 0042470 | cellular_component | melanosome |
A | 0070062 | cellular_component | extracellular exosome |
B | 0004013 | molecular_function | adenosylhomocysteinase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005634 | cellular_component | nucleus |
B | 0005737 | cellular_component | cytoplasm |
B | 0005783 | cellular_component | endoplasmic reticulum |
B | 0005829 | cellular_component | cytosol |
B | 0006730 | biological_process | one-carbon metabolic process |
B | 0016787 | molecular_function | hydrolase activity |
B | 0033353 | biological_process | S-adenosylmethionine cycle |
B | 0042470 | cellular_component | melanosome |
B | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 27 |
Details | binding site for residue NAD A 501 |
Chain | Residue |
A | THR157 |
A | GLU243 |
A | ILE244 |
A | ASP245 |
A | ASN248 |
A | THR275 |
A | THR276 |
A | GLY277 |
A | ILE281 |
A | ILE299 |
A | GLY300 |
A | THR158 |
A | HIS301 |
A | ASN346 |
A | HIS353 |
A | GLN413 |
A | LYS426 |
A | TYR430 |
A | ADN502 |
A | HOH606 |
A | THR159 |
A | ASN191 |
A | GLY220 |
A | GLY222 |
A | ASP223 |
A | VAL224 |
A | THR242 |
site_id | AC2 |
Number of Residues | 15 |
Details | binding site for residue ADN A 502 |
Chain | Residue |
A | HIS55 |
A | THR57 |
A | GLU59 |
A | THR60 |
A | GLU156 |
A | THR157 |
A | LYS186 |
A | ASP190 |
A | HIS301 |
A | LEU344 |
A | MET351 |
A | HIS353 |
A | MET358 |
A | PHE362 |
A | NAD501 |
site_id | AC3 |
Number of Residues | 25 |
Details | binding site for residue NAD B 501 |
Chain | Residue |
B | THR157 |
B | THR158 |
B | THR159 |
B | ASN191 |
B | GLY220 |
B | GLY222 |
B | ASP223 |
B | VAL224 |
B | THR242 |
B | GLU243 |
B | ILE244 |
B | ASN248 |
B | THR275 |
B | THR276 |
B | GLY277 |
B | CYS278 |
B | ILE281 |
B | ILE299 |
B | GLY300 |
B | HIS301 |
B | ASN346 |
B | HIS353 |
B | LYS426 |
B | TYR430 |
B | ADN502 |
site_id | AC4 |
Number of Residues | 14 |
Details | binding site for residue ADN B 502 |
Chain | Residue |
B | HIS55 |
B | THR57 |
B | GLU59 |
B | THR60 |
B | ASP131 |
B | GLU156 |
B | THR157 |
B | LYS186 |
B | ASP190 |
B | HIS301 |
B | MET351 |
B | HIS353 |
B | MET358 |
B | NAD501 |
Functional Information from PROSITE/UniProt
site_id | PS00738 |
Number of Residues | 15 |
Details | ADOHCYASE_1 S-adenosyl-L-homocysteine hydrolase signature 1. SCNiFSTQNhAAAAI |
Chain | Residue | Details |
A | SER78-ILE92 | |
site_id | PS00739 |
Number of Residues | 17 |
Details | ADOHCYASE_2 S-adenosyl-L-homocysteine hydrolase signature 2. GKvavVaGYGdVGKGc.A |
Chain | Residue | Details |
A | GLY213-ALA229 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | THR57 | |
B | ASP190 | |
A | ASP131 | |
A | GLU156 | |
A | LYS186 | |
A | ASP190 | |
B | THR57 | |
B | ASP131 | |
B | GLU156 | |
B | LYS186 | |
Chain | Residue | Details |
A | THR157 | |
B | GLU243 | |
B | ASN248 | |
B | ILE299 | |
B | ASN346 | |
B | HIS353 | |
A | GLY222 | |
A | GLU243 | |
A | ASN248 | |
A | ILE299 | |
A | ASN346 | |
A | HIS353 | |
B | THR157 | |
B | GLY222 | |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: N-acetylserine => ECO:0000269|Ref.8 |
Chain | Residue | Details |
A | SER2 | |
B | SER2 | |
Chain | Residue | Details |
A | SER183 | |
B | SER183 | |
Chain | Residue | Details |
A | LYS186 | |
B | LYS186 | |
Chain | Residue | Details |
A | TYR193 | |
B | TYR193 | |