4PG4
Crystal structure of S. aureus Homoserine Dehydrogenase at pH6.0
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004412 | molecular_function | homoserine dehydrogenase activity |
A | 0006520 | biological_process | amino acid metabolic process |
A | 0009086 | biological_process | methionine biosynthetic process |
A | 0009088 | biological_process | threonine biosynthetic process |
A | 0009097 | biological_process | isoleucine biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0050661 | molecular_function | NADP binding |
B | 0004412 | molecular_function | homoserine dehydrogenase activity |
B | 0006520 | biological_process | amino acid metabolic process |
B | 0009086 | biological_process | methionine biosynthetic process |
B | 0009088 | biological_process | threonine biosynthetic process |
B | 0009097 | biological_process | isoleucine biosynthetic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | binding site for residue ACT A 501 |
Chain | Residue |
A | VAL79 |
A | MET80 |
A | GLY81 |
A | ALA103 |
A | LYS105 |
site_id | AC2 |
Number of Residues | 3 |
Details | binding site for residue ACT A 502 |
Chain | Residue |
A | LEU242 |
A | TYR244 |
A | ASP269 |
site_id | AC3 |
Number of Residues | 2 |
Details | binding site for residue ACT A 503 |
Chain | Residue |
A | GLU264 |
A | ARG226 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue ACT A 504 |
Chain | Residue |
A | GLY10 |
A | LEU11 |
A | VAL44 |
A | ARG45 |
site_id | AC5 |
Number of Residues | 2 |
Details | binding site for residue ACT A 505 |
Chain | Residue |
A | ASP181 |
B | HIS382 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue ACT A 506 |
Chain | Residue |
A | GLN216 |
A | VAL217 |
A | GLY257 |
A | VAL259 |
site_id | AC7 |
Number of Residues | 3 |
Details | binding site for residue ACT A 507 |
Chain | Residue |
A | VAL223 |
A | LYS224 |
A | ARG225 |
site_id | AC8 |
Number of Residues | 5 |
Details | binding site for residue ACT A 508 |
Chain | Residue |
A | LEU108 |
A | LYS219 |
A | LEU220 |
A | HOH647 |
A | HOH665 |
site_id | AC9 |
Number of Residues | 3 |
Details | binding site for residue ACT A 509 |
Chain | Residue |
A | ASN69 |
A | HIS382 |
A | ARG383 |
site_id | AD1 |
Number of Residues | 4 |
Details | binding site for residue ACT A 510 |
Chain | Residue |
A | TYR281 |
A | TYR297 |
A | HOH612 |
B | TYR285 |
site_id | AD2 |
Number of Residues | 5 |
Details | binding site for residue GOL A 511 |
Chain | Residue |
A | LYS3 |
A | ASN5 |
A | SER72 |
A | ASP74 |
B | GLU416 |
site_id | AD3 |
Number of Residues | 6 |
Details | binding site for residue PEG A 512 |
Chain | Residue |
A | GLU190 |
A | ASP192 |
A | PRO193 |
A | THR194 |
A | ASP195 |
A | ASP196 |
site_id | AD4 |
Number of Residues | 3 |
Details | binding site for residue PEG A 513 |
Chain | Residue |
A | GLY230 |
A | ASP418 |
A | LYS419 |
site_id | AD5 |
Number of Residues | 6 |
Details | binding site for residue ACT B 501 |
Chain | Residue |
A | LYS412 |
A | HIS413 |
B | LYS376 |
B | ALA377 |
B | LEU379 |
B | PHE381 |
site_id | AD6 |
Number of Residues | 2 |
Details | binding site for residue ACT B 502 |
Chain | Residue |
B | HIS413 |
B | GLY414 |
site_id | AD7 |
Number of Residues | 4 |
Details | binding site for residue ACT B 503 |
Chain | Residue |
B | ASP240 |
B | GLN241 |
B | GLY243 |
B | LYS270 |
site_id | AD8 |
Number of Residues | 4 |
Details | binding site for residue ACT B 504 |
Chain | Residue |
B | TYR244 |
B | ARG386 |
B | VAL398 |
B | VAL400 |
site_id | AD9 |
Number of Residues | 3 |
Details | binding site for residue ACT B 505 |
Chain | Residue |
B | ARG26 |
B | ILE39 |
B | TYR58 |
site_id | AE1 |
Number of Residues | 4 |
Details | binding site for residue ACT B 506 |
Chain | Residue |
B | ARG226 |
B | LYS419 |
B | GOL508 |
B | HOH621 |
site_id | AE2 |
Number of Residues | 5 |
Details | binding site for residue ACT B 507 |
Chain | Residue |
B | LEU108 |
B | LYS219 |
B | LEU220 |
B | HOH601 |
B | HOH652 |
site_id | AE3 |
Number of Residues | 5 |
Details | binding site for residue GOL B 508 |
Chain | Residue |
A | GLN30 |
B | GLY230 |
B | ASP418 |
B | LYS419 |
B | ACT506 |
site_id | AE4 |
Number of Residues | 3 |
Details | binding site for residue GOL B 509 |
Chain | Residue |
A | ASP240 |
A | LYS270 |
B | ASP46 |
site_id | AE5 |
Number of Residues | 7 |
Details | binding site for residue PEG B 510 |
Chain | Residue |
B | LYS47 |
B | HIS59 |
B | LEU60 |
B | THR61 |
B | GLU66 |
B | THR170 |
B | LYS171 |
site_id | AE6 |
Number of Residues | 5 |
Details | binding site for residue DMS B 511 |
Chain | Residue |
B | VAL79 |
B | MET80 |
B | GLY81 |
B | ALA103 |
B | LYS105 |
site_id | AE7 |
Number of Residues | 4 |
Details | binding site for residue DMS B 512 |
Chain | Residue |
B | ASP269 |
B | ARG386 |
B | LEU242 |
B | TYR244 |
Functional Information from PROSITE/UniProt
site_id | PS01042 |
Number of Residues | 23 |
Details | HOMOSER_DHGENASE Homoserine dehydrogenase signature. AkrlGFAea.DPtdDVeGvDaarK |
Chain | Residue | Details |
A | ALA183-LYS205 |