Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4PFQ

Crystal structure of hypoxanthine phosphoribosyltransferase from Brachybacterium faecium DSM 4810, NYSGRC Target 029763.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006166	biological_process	purine ribonucleoside salvage
A	0006178	biological_process	guanine salvage
A	0016757	molecular_function	glycosyltransferase activity
A	0032263	biological_process	GMP salvage
A	0032264	biological_process	IMP salvage
A	0046100	biological_process	hypoxanthine metabolic process
A	0046872	molecular_function	metal ion binding
A	0052657	molecular_function	guanine phosphoribosyltransferase activity
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006166	biological_process	purine ribonucleoside salvage
B	0006178	biological_process	guanine salvage
B	0016757	molecular_function	glycosyltransferase activity
B	0032263	biological_process	GMP salvage
B	0032264	biological_process	IMP salvage
B	0046100	biological_process	hypoxanthine metabolic process
B	0046872	molecular_function	metal ion binding
B	0052657	molecular_function	guanine phosphoribosyltransferase activity
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006166	biological_process	purine ribonucleoside salvage
C	0006178	biological_process	guanine salvage
C	0016757	molecular_function	glycosyltransferase activity
C	0032263	biological_process	GMP salvage
C	0032264	biological_process	IMP salvage
C	0046100	biological_process	hypoxanthine metabolic process
C	0046872	molecular_function	metal ion binding
C	0052657	molecular_function	guanine phosphoribosyltransferase activity
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006166	biological_process	purine ribonucleoside salvage
D	0006178	biological_process	guanine salvage
D	0016757	molecular_function	glycosyltransferase activity
D	0032263	biological_process	GMP salvage
D	0032264	biological_process	IMP salvage
D	0046100	biological_process	hypoxanthine metabolic process
D	0046872	molecular_function	metal ion binding
D	0052657	molecular_function	guanine phosphoribosyltransferase activity
E	0000166	molecular_function	nucleotide binding
E	0000287	molecular_function	magnesium ion binding
E	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006166	biological_process	purine ribonucleoside salvage
E	0006178	biological_process	guanine salvage
E	0016757	molecular_function	glycosyltransferase activity
E	0032263	biological_process	GMP salvage
E	0032264	biological_process	IMP salvage
E	0046100	biological_process	hypoxanthine metabolic process
E	0046872	molecular_function	metal ion binding
E	0052657	molecular_function	guanine phosphoribosyltransferase activity
F	0000166	molecular_function	nucleotide binding
F	0000287	molecular_function	magnesium ion binding
F	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006166	biological_process	purine ribonucleoside salvage
F	0006178	biological_process	guanine salvage
F	0016757	molecular_function	glycosyltransferase activity
F	0032263	biological_process	GMP salvage
F	0032264	biological_process	IMP salvage
F	0046100	biological_process	hypoxanthine metabolic process
F	0046872	molecular_function	metal ion binding
F	0052657	molecular_function	guanine phosphoribosyltransferase activity
G	0000166	molecular_function	nucleotide binding
G	0000287	molecular_function	magnesium ion binding
G	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006166	biological_process	purine ribonucleoside salvage
G	0006178	biological_process	guanine salvage
G	0016757	molecular_function	glycosyltransferase activity
G	0032263	biological_process	GMP salvage
G	0032264	biological_process	IMP salvage
G	0046100	biological_process	hypoxanthine metabolic process
G	0046872	molecular_function	metal ion binding
G	0052657	molecular_function	guanine phosphoribosyltransferase activity
H	0000166	molecular_function	nucleotide binding
H	0000287	molecular_function	magnesium ion binding
H	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006166	biological_process	purine ribonucleoside salvage
H	0006178	biological_process	guanine salvage
H	0016757	molecular_function	glycosyltransferase activity
H	0032263	biological_process	GMP salvage
H	0032264	biological_process	IMP salvage
H	0046100	biological_process	hypoxanthine metabolic process
H	0046872	molecular_function	metal ion binding
H	0052657	molecular_function	guanine phosphoribosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue MG A 400

Chain	Residue
A	GLU126
A	ASP127
A	HOH507
A	HOH509
A	HOH548

site_id	AC2
Number of Residues	5
Details	binding site for residue MG B 400

Chain	Residue
B	HOH559
B	GLU126
B	ASP127
B	HOH509
B	HOH510

site_id	AC3
Number of Residues	2
Details	binding site for residue MG B 401

Chain	Residue
B	ASP165
D	HOH545

site_id	AC4
Number of Residues	4
Details	binding site for residue MG C 400

Chain	Residue
C	GLU126
C	ASP127
C	HOH548
C	HOH562

site_id	AC5
Number of Residues	5
Details	binding site for residue MG D 400

Chain	Residue
D	GLU126
D	ASP127
D	HOH508
D	HOH511
D	HOH549

site_id	AC6
Number of Residues	3
Details	binding site for residue MG D 401

Chain	Residue
D	HOH505
F	HOH502
F	HOH506

site_id	AC7
Number of Residues	4
Details	binding site for residue MG E 400

Chain	Residue
E	GLU126
E	ASP127
E	HOH541
E	HOH564

site_id	AC8
Number of Residues	3
Details	binding site for residue MG E 401

Chain	Residue
E	HOH501
E	HOH504
E	HOH505

site_id	AC9
Number of Residues	6
Details	binding site for residue MG F 400

Chain	Residue
F	GLU126
F	ASP127
F	HOH543
F	HOH560
F	HOH561
F	HOH574

site_id	AD1
Number of Residues	5
Details	binding site for residue MG G 400

Chain	Residue
G	GLU126
G	ASP127
G	HOH505
G	HOH510
G	HOH544

site_id	AD2
Number of Residues	5
Details	binding site for residue MG H 400

Chain	Residue
H	GLU126
H	ASP127
H	HOH549
H	HOH550
H	HOH551

site_id	AD3
Number of Residues	1
Details	binding site for residue MG H 401

Chain	Residue
H	HOH501

Functional Information from PROSITE/UniProt

site_id	PS00103
Number of Residues	13
Details	PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VLIVEDIIDSGlT

Chain	Residue	Details
A	VAL122-THR134

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)