4PFN

Crystal structure of Plasmodium vivax SHMT with L-serine Schiff base

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004372	molecular_function	glycine hydroxymethyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0006565	biological_process	L-serine catabolic process
A	0006730	biological_process	one-carbon metabolic process
A	0008270	molecular_function	zinc ion binding
A	0016740	molecular_function	transferase activity
A	0019264	biological_process	glycine biosynthetic process from serine
A	0030170	molecular_function	pyridoxal phosphate binding
A	0035999	biological_process	tetrahydrofolate interconversion
A	0046653	biological_process	tetrahydrofolate metabolic process
A	0046655	biological_process	folic acid metabolic process
A	0050897	molecular_function	cobalt ion binding
A	0070905	molecular_function	serine binding
B	0004372	molecular_function	glycine hydroxymethyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0006565	biological_process	L-serine catabolic process
B	0006730	biological_process	one-carbon metabolic process
B	0008270	molecular_function	zinc ion binding
B	0016740	molecular_function	transferase activity
B	0019264	biological_process	glycine biosynthetic process from serine
B	0030170	molecular_function	pyridoxal phosphate binding
B	0035999	biological_process	tetrahydrofolate interconversion
B	0046653	biological_process	tetrahydrofolate metabolic process
B	0046655	biological_process	folic acid metabolic process
B	0050897	molecular_function	cobalt ion binding
B	0070905	molecular_function	serine binding
C	0004372	molecular_function	glycine hydroxymethyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0006565	biological_process	L-serine catabolic process
C	0006730	biological_process	one-carbon metabolic process
C	0008270	molecular_function	zinc ion binding
C	0016740	molecular_function	transferase activity
C	0019264	biological_process	glycine biosynthetic process from serine
C	0030170	molecular_function	pyridoxal phosphate binding
C	0035999	biological_process	tetrahydrofolate interconversion
C	0046653	biological_process	tetrahydrofolate metabolic process
C	0046655	biological_process	folic acid metabolic process
C	0050897	molecular_function	cobalt ion binding
C	0070905	molecular_function	serine binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue CL B 503

Chain	Residue
A	ASN276
A	LYS277
B	ASN276
B	LYS277

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site_id	AC2
Number of Residues	4
Details	binding site for residue CL C 503

Chain	Residue
C	ASN276
C	ASN276
C	LYS277
C	LYS277

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site_id	AC3
Number of Residues	20
Details	binding site for Di-peptide PLP A 501 and SER A 502

Chain	Residue
A	SER100
A	GLY101
A	SER102
A	HIS129
A	TYR182
A	THR183
A	ASP208
A	HIS211
A	THR234
A	HIS236
A	LYS237
A	ARG371
A	HOH659
A	HOH673
A	HOH711
B	TYR54
B	GLU56
B	TYR64
B	GLY272
A	SER34

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site_id	AC4
Number of Residues	22
Details	binding site for Di-peptide PLP B 501 and SER B 502

Chain	Residue
A	TYR54
A	GLU56
A	TYR64
A	GLY272
B	SER34
B	SER100
B	GLY101
B	SER102
B	HIS129
B	TYR182
B	THR183
B	ASP208
B	SER210
B	HIS211
B	THR234
B	HIS236
B	LYS237
B	ARG371
B	HOH618
B	HOH661
B	HOH712
B	HOH731

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site_id	AC5
Number of Residues	22
Details	binding site for Di-peptide PLP C 501 and SER C 502

Chain	Residue
C	SER34
C	TYR54
C	GLU56
C	TYR64
C	SER100
C	GLY101
C	SER102
C	HIS129
C	TYR182
C	THR183
C	ASP208
C	SER210
C	HIS211
C	THR234
C	HIS236
C	LYS237
C	GLY271
C	GLY272
C	ARG371
C	HOH615
C	HOH617
C	HOH621

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