4PFK

PHOSPHOFRUCTOKINASE. STRUCTURE AND CONTROL

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003872	molecular_function	6-phosphofructokinase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005945	cellular_component	6-phosphofructokinase complex
A	0006002	biological_process	fructose 6-phosphate metabolic process
A	0006096	biological_process	glycolytic process
A	0008443	molecular_function	phosphofructokinase activity
A	0016020	cellular_component	membrane
A	0016208	molecular_function	AMP binding
A	0016301	molecular_function	kinase activity
A	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0048029	molecular_function	monosaccharide binding
A	0061621	biological_process	canonical glycolysis
A	0070095	molecular_function	fructose-6-phosphate binding

Functional Information from PROSITE/UniProt

site_id	PS00433
Number of Residues	19
Details	PHOSPHOFRUCTOKINASE Phosphofructokinase signature. RvtvlGHvQRGGsptafDR

Chain	Residue	Details
A	ARG243-ARG261

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00339

Chain	Residue	Details
A	ASP127

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00339

Chain	Residue	Details
A	GLY11
A	GLY102

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site_id	SWS_FT_FI3
Number of Residues	5
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00339, ECO:0000269|PubMed:6115424

Chain	Residue	Details
A	ARG21
A	ASP59
A	ARG72
A	ASP103
A	ARG162

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site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_00339, ECO:0000269|PubMed:12390023, ECO:0000269|PubMed:6115424

Chain	Residue	Details
A	THR125
A	MET169
A	GLU222
A	HIS249

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site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_00339, ECO:0000269|PubMed:6115424

Chain	Residue	Details
A	ARG154
A	GLY185
A	ARG211
A	LYS213

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site_id	SWS_FT_FI6
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00339, ECO:0000269|PubMed:12390023, ECO:0000269|PubMed:6115424

Chain	Residue	Details
A	ARG243

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	5
Details	Annotated By Reference To The Literature 1pfk

Chain	Residue	Details
A	GLY11
A	ASP127
A	THR125
A	ARG72
A	ARG171

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