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4PFF

Crystal structure of Plasmodium vivax SHMT with PLP Schiff base

Functional Information from GO Data
ChainGOidnamespacecontents
A0000900molecular_functionmRNA regulatory element binding translation repressor activity
A0004372molecular_functionglycine hydroxymethyltransferase activity
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006565biological_processL-serine catabolic process
A0008270molecular_functionzinc ion binding
A0009113biological_processpurine nucleobase biosynthetic process
A0016740molecular_functiontransferase activity
A0017148biological_processnegative regulation of translation
A0019264biological_processglycine biosynthetic process from serine
A0030170molecular_functionpyridoxal phosphate binding
A0035999biological_processtetrahydrofolate interconversion
A0042803molecular_functionprotein homodimerization activity
A0046655biological_processfolic acid metabolic process
A0048027molecular_functionmRNA 5'-UTR binding
A0050897molecular_functioncobalt ion binding
A0051289biological_processprotein homotetramerization
A0070905molecular_functionserine binding
A1990830biological_processcellular response to leukemia inhibitory factor
B0000900molecular_functionmRNA regulatory element binding translation repressor activity
B0004372molecular_functionglycine hydroxymethyltransferase activity
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006565biological_processL-serine catabolic process
B0008270molecular_functionzinc ion binding
B0009113biological_processpurine nucleobase biosynthetic process
B0016740molecular_functiontransferase activity
B0017148biological_processnegative regulation of translation
B0019264biological_processglycine biosynthetic process from serine
B0030170molecular_functionpyridoxal phosphate binding
B0035999biological_processtetrahydrofolate interconversion
B0042803molecular_functionprotein homodimerization activity
B0046655biological_processfolic acid metabolic process
B0048027molecular_functionmRNA 5'-UTR binding
B0050897molecular_functioncobalt ion binding
B0051289biological_processprotein homotetramerization
B0070905molecular_functionserine binding
B1990830biological_processcellular response to leukemia inhibitory factor
C0000900molecular_functionmRNA regulatory element binding translation repressor activity
C0004372molecular_functionglycine hydroxymethyltransferase activity
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006565biological_processL-serine catabolic process
C0008270molecular_functionzinc ion binding
C0009113biological_processpurine nucleobase biosynthetic process
C0016740molecular_functiontransferase activity
C0017148biological_processnegative regulation of translation
C0019264biological_processglycine biosynthetic process from serine
C0030170molecular_functionpyridoxal phosphate binding
C0035999biological_processtetrahydrofolate interconversion
C0042803molecular_functionprotein homodimerization activity
C0046655biological_processfolic acid metabolic process
C0048027molecular_functionmRNA 5'-UTR binding
C0050897molecular_functioncobalt ion binding
C0051289biological_processprotein homotetramerization
C0070905molecular_functionserine binding
C1990830biological_processcellular response to leukemia inhibitory factor
Functional Information from PDB Data
site_idAC1
Number of Residues14
Detailsbinding site for residue PLP A 501
ChainResidue
ASER100
AHIS236
ALYS237
AARG243
AHOH747
BTYR54
AGLY101
ASER102
AHIS129
ATYR182
ATHR183
AASP208
AHIS211
ATHR234

site_idAC2
Number of Residues18
Detailsbinding site for Di-peptide PLP B 501 and LYS B 237
ChainResidue
ATYR54
BSER34
BASN36
BSER100
BGLY101
BSER102
BHIS129
BTYR182
BTHR183
BASP208
BHIS211
BTHR234
BHIS236
BILE238
BLEU239
BARG240
BARG243
BHOH761

site_idAC3
Number of Residues19
Detailsbinding site for Di-peptide PLP C 501 and LYS C 237
ChainResidue
CSER34
CASN36
CTYR54
CSER100
CGLY101
CSER102
CASN105
CHIS129
CTHR183
CASP208
CHIS211
CTHR234
CHIS236
CILE238
CLEU239
CARG240
CARG243
CHOH646
CHOH691

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PDB entries from 2024-06-12

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