4PF4

1.1A X-RAY STRUCTURE OF THE APO CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE 1, aa 1-277

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue SO4 A 301

Chain	Residue
A	LYS86
A	LYS249
A	ARG253
A	GOL309
A	HOH488
A	HOH553
A	HOH880

---

site_id	AC2
Number of Residues	4
Details	binding site for residue SO4 A 302

Chain	Residue
A	ARG254
A	HOH801
A	LYS222
A	LEU226

---

site_id	AC3
Number of Residues	8
Details	binding site for residue SO4 A 303

Chain	Residue
A	GLY22
A	GLN23
A	HOH712
A	HOH720
A	HOH791
A	HOH815
A	HOH833
A	HOH843

---

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 A 304

Chain	Residue
A	ARG63
A	HOH682
A	HOH717
A	HOH766

---

site_id	AC5
Number of Residues	6
Details	binding site for residue NA A 305

Chain	Residue
A	GLU32
A	THR35
A	LEU37
A	TYR39
A	HIS80
A	SER132

---

site_id	AC6
Number of Residues	9
Details	binding site for residue GOL A 306

Chain	Residue
A	ALA40
A	GLU94
A	LEU95
A	VAL96
A	MET146
A	ILE160
A	HOH783
A	HOH831
A	HOH870

---

site_id	AC7
Number of Residues	10
Details	binding site for residue GOL A 307

Chain	Residue
A	PHE102
A	PRO142
A	GLU143
A	GLU182
A	PHE183
A	ILE209
A	HOH750
A	HOH751
A	HOH772
A	HOH885

---

site_id	AC8
Number of Residues	8
Details	binding site for residue GOL A 308

Chain	Residue
A	LYS42
A	VAL56
A	GLU64
A	ASP161
A	HOH681
A	HOH718
A	HOH720
A	HOH833

---

site_id	AC9
Number of Residues	8
Details	binding site for residue GOL A 309

Chain	Residue
A	TYR234
A	GLU235
A	PHE236
A	ARG253
A	SO4301
A	HOH407
A	HOH553
A	HOH834

---

site_id	AD1
Number of Residues	7
Details	binding site for residue GOL A 310

Chain	Residue
A	VAL26
A	ASP88
A	ASN243
A	HOH467
A	HOH518
A	HOH547
A	HOH868

---

site_id	AD2
Number of Residues	12
Details	binding site for residue GOL A 311

Chain	Residue
A	ARG5
A	TYR12
A	GLU32
A	SER34
A	TYR128
A	GLN271
A	HOH403
A	HOH404
A	HOH411
A	HOH451
A	HOH512
A	HOH672

---

site_id	AD3
Number of Residues	4
Details	binding site for residue NA A 312

Chain	Residue
A	GLN72
A	HIS73
A	ASP169
A	HOH497

---

site_id	AD4
Number of Residues	3
Details	binding site for residue MG A 313

Chain	Residue
A	LYS42
A	ASP161
A	HOH870

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	28
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGQFAVVKkCrekstglqyaak......FIKK

Chain	Residue	Details
A	LEU19-LYS46

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IaHfDLKpeNIML

Chain	Residue	Details
A	ILE135-LEU147

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	262
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	13
Details	Binding site: {}

Chain

Residue

Details

---