4PE7
Crystal Structure of Calcium-loaded S100B bound to SC1982
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001726 | cellular_component | ruffle |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006417 | biological_process | regulation of translation |
| A | 0007155 | biological_process | cell adhesion |
| A | 0007409 | biological_process | axonogenesis |
| A | 0007611 | biological_process | learning or memory |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0016310 | biological_process | phosphorylation |
| A | 0019210 | molecular_function | kinase inhibitor activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| A | 0044548 | molecular_function | S100 protein binding |
| A | 0045666 | biological_process | positive regulation of neuron differentiation |
| A | 0045917 | biological_process | positive regulation of complement activation |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048143 | biological_process | astrocyte activation |
| A | 0048156 | molecular_function | tau protein binding |
| A | 0048306 | molecular_function | calcium-dependent protein binding |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0050786 | molecular_function | RAGE receptor binding |
| A | 0071638 | biological_process | negative regulation of monocyte chemotactic protein-1 production |
| A | 0097490 | biological_process | sympathetic neuron projection extension |
| A | 1990138 | biological_process | neuron projection extension |
| A | 1990845 | biological_process | adaptive thermogenesis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue ODN A 101 |
| Chain | Residue |
| A | MET0 |
| A | HIS42 |
| A | HIS42 |
| A | PHE43 |
| A | CYS84 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 102 |
| Chain | Residue |
| A | GLU31 |
| A | HOH299 |
| A | SER18 |
| A | GLU21 |
| A | ASP23 |
| A | LYS26 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 103 |
| Chain | Residue |
| A | ASP61 |
| A | ASP63 |
| A | ASP65 |
| A | GLU67 |
| A | GLU72 |
| A | HOH296 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue CA A 104 |
| Chain | Residue |
| A | ASP63 |
| A | ASP69 |
| A | HOH208 |
| A | HOH214 |
| A | HOH216 |
| A | HOH246 |
| A | HOH278 |
| A | HOH283 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 35 |
| Details | Domain: {"description":"EF-hand 1","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 35 |
| Details | Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P04271","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"4026304","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
