4PA4
Structure of NavMS in complex with channel blocking compound
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005227 | molecular_function | calcium-activated cation channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0030317 | biological_process | flagellated sperm motility |
| A | 0036128 | cellular_component | CatSper complex |
| A | 0055085 | biological_process | transmembrane transport |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005227 | molecular_function | calcium-activated cation channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0030317 | biological_process | flagellated sperm motility |
| B | 0036128 | cellular_component | CatSper complex |
| B | 0055085 | biological_process | transmembrane transport |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005227 | molecular_function | calcium-activated cation channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0030317 | biological_process | flagellated sperm motility |
| C | 0036128 | cellular_component | CatSper complex |
| C | 0055085 | biological_process | transmembrane transport |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005227 | molecular_function | calcium-activated cation channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0030317 | biological_process | flagellated sperm motility |
| D | 0036128 | cellular_component | CatSper complex |
| D | 0055085 | biological_process | transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue 2CV A 301 |
| Chain | Residue |
| A | SER165 |
| A | LYS166 |
| B | PRO193 |
| B | ASN194 |
| B | TRP196 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue 12P A 302 |
| Chain | Residue |
| A | PHE198 |
| A | TYR153 |
| A | HIS192 |
| A | ASN194 |
| A | VAL197 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue 2CV A 303 |
| Chain | Residue |
| A | PRO193 |
| A | ASN194 |
| A | TRP196 |
| B | PHE142 |
| B | SER165 |
| B | LYS166 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue NA A 304 |
| Chain | Residue |
| A | NA305 |
| A | NA305 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 305 |
| Chain | Residue |
| A | NA304 |
| A | NA304 |
| A | NA306 |
| A | NA306 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 306 |
| Chain | Residue |
| A | NA305 |
| A | NA305 |
| B | NA302 |
| B | NA302 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue BR A 307 |
| Chain | Residue |
| B | 12P301 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | binding site for residue 12P B 301 |
| Chain | Residue |
| A | PHE214 |
| A | BR307 |
| B | TYR153 |
| B | HIS192 |
| B | ASN194 |
| B | VAL197 |
| B | PHE198 |
| B | ILE203 |
| B | MET204 |
| B | THR207 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue NA B 302 |
| Chain | Residue |
| A | NA306 |
| A | NA306 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue 2CV C 301 |
| Chain | Residue |
| C | SER165 |
| D | PRO193 |
| D | TRP196 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue 2CV C 302 |
| Chain | Residue |
| C | PRO193 |
| C | TRP196 |
| D | SER165 |
| D | LYS166 |
| site_id | AD3 |
| Number of Residues | 1 |
| Details | binding site for residue BR C 303 |
| Chain | Residue |
| C | MET175 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue NA D 401 |
| Chain | Residue |
| D | NA403 |
| D | NA403 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue NA D 402 |
| Chain | Residue |
| D | NA403 |
| D | NA403 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue NA D 403 |
| Chain | Residue |
| D | NA401 |
| D | NA401 |
| D | NA402 |
| D | NA402 |
