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4P9S

Crystal structure of the mature form of rat DMGDH

Functional Information from GO Data
ChainGOidnamespacecontents
A0005542molecular_functionfolic acid binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0006579biological_processamino-acid betaine catabolic process
A0016491molecular_functionoxidoreductase activity
A0019695biological_processcholine metabolic process
A0035999biological_processtetrahydrofolate interconversion
A0042426biological_processcholine catabolic process
A0047865molecular_functiondimethylglycine dehydrogenase activity
A0050660molecular_functionflavin adenine dinucleotide binding
B0005542molecular_functionfolic acid binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0006579biological_processamino-acid betaine catabolic process
B0016491molecular_functionoxidoreductase activity
B0019695biological_processcholine metabolic process
B0035999biological_processtetrahydrofolate interconversion
B0042426biological_processcholine catabolic process
B0047865molecular_functiondimethylglycine dehydrogenase activity
B0050660molecular_functionflavin adenine dinucleotide binding
Functional Information from PDB Data
site_idAC1
Number of Residues34
Detailsbinding site for residue FAD A 901
ChainResidue
AILE48
AGLY80
ASER81
ATHR82
AHIS84
AALA85
AALA86
AGLY87
ALEU88
APRO211
AVAL212
AGLY49
AALA240
AALA241
AGLY242
ATRP244
AHIS263
ATYR265
AGLY363
APRO364
AILE365
APHE390
AGLY51
ATYR392
AGLY393
AILE394
AILE395
AHOH1022
ACYS52
AVAL53
ALEU72
AGLU73
ALYS74
AALA79

site_idAC2
Number of Residues38
Detailsbinding site for residue FAD B 901
ChainResidue
BILE48
BGLY49
BGLY51
BCYS52
BVAL53
BLEU72
BGLU73
BLYS74
BALA79
BGLY80
BSER81
BTHR82
BHIS84
BALA85
BALA86
BGLY87
BLEU88
BPRO211
BVAL212
BALA240
BALA241
BGLY242
BTRP244
BHIS263
BTYR265
BGLY363
BPRO364
BILE365
BPHE390
BTYR392
BGLY393
BILE394
BILE395
BHOH1009
BHOH1039
BHOH1045
BHOH1046
BHOH1053

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsBINDING: BINDING => ECO:0000269|PubMed:24858690, ECO:0007744|PDB:4P9S, ECO:0007744|PDB:4PAA, ECO:0007744|PDB:4PAB
ChainResidueDetails
ACYS52
BPHE390
AGLU73
AGLY80
AVAL212
APHE390
BCYS52
BGLU73
BGLY80
BVAL212

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:24858690, ECO:0007744|PDB:4P9S, ECO:0007744|PDB:4PAB
ChainResidueDetails
ATRP244
BTRP244

site_idSWS_FT_FI3
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:24858690, ECO:0007744|PDB:4PAA, ECO:0007744|PDB:4PAB
ChainResidueDetails
AGLU573
AGLU676
ATYR737
BGLU573
BGLU676
BTYR737

site_idSWS_FT_FI4
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:24858690, ECO:0007744|PDB:4PAA
ChainResidueDetails
ATYR669
BTYR669

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Tele-8alpha-FAD histidine => ECO:0000269|PubMed:24858690, ECO:0000269|PubMed:4055729, ECO:0007744|PDB:4P9S, ECO:0007744|PDB:4PAA, ECO:0007744|PDB:4PAB
ChainResidueDetails
AHIS84
BHIS84

site_idSWS_FT_FI6
Number of Residues12
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9DBT9
ChainResidueDetails
ALYS107
BLYS328
BLYS353
BLYS757
ALYS161
ALYS216
ALYS328
ALYS353
ALYS757
BLYS107
BLYS161
BLYS216

site_idSWS_FT_FI7
Number of Residues12
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9DBT9
ChainResidueDetails
ALYS141
BLYS516
BLYS648
BLYS786
ALYS427
ALYS469
ALYS516
ALYS648
ALYS786
BLYS141
BLYS427
BLYS469

site_idSWS_FT_FI8
Number of Residues6
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9DBT9
ChainResidueDetails
ALYS310
ALYS312
ALYS788
BLYS310
BLYS312
BLYS788

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PDB entries from 2024-11-20

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