4P8R
Structure of a glycosomal glyceraldehyde 3-phosphate dehydrogenase from Trypanosoma brucei
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004365 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006006 | biological_process | glucose metabolic process |
| A | 0006096 | biological_process | glycolytic process |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| A | 0050661 | molecular_function | NADP binding |
| A | 0051287 | molecular_function | NAD binding |
| B | 0004365 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006006 | biological_process | glucose metabolic process |
| B | 0006096 | biological_process | glycolytic process |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0050661 | molecular_function | NADP binding |
| B | 0051287 | molecular_function | NAD binding |
| C | 0004365 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006006 | biological_process | glucose metabolic process |
| C | 0006096 | biological_process | glycolytic process |
| C | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| C | 0050661 | molecular_function | NADP binding |
| C | 0051287 | molecular_function | NAD binding |
| D | 0004365 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006006 | biological_process | glucose metabolic process |
| D | 0006096 | biological_process | glycolytic process |
| D | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| D | 0050661 | molecular_function | NADP binding |
| D | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | binding site for residue NAD A 400 |
| Chain | Residue |
| A | ASN8 |
| A | THR97 |
| A | GLY98 |
| A | LEU99 |
| A | THR120 |
| A | CYS150 |
| A | ALA181 |
| A | ASN314 |
| A | TYR318 |
| A | HOH524 |
| A | HOH576 |
| A | GLY9 |
| A | HOH623 |
| A | HOH624 |
| A | HOH628 |
| A | HOH638 |
| A | HOH639 |
| A | HOH652 |
| B | PRO189 |
| A | GLY11 |
| A | ARG12 |
| A | ILE13 |
| A | ASN33 |
| A | ASP34 |
| A | ARG78 |
| A | SER96 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 401 |
| Chain | Residue |
| A | ALA21 |
| A | ARG24 |
| A | ILE27 |
| A | HOH559 |
| site_id | AC3 |
| Number of Residues | 25 |
| Details | binding site for residue NAD B 400 |
| Chain | Residue |
| A | PRO189 |
| B | ASN8 |
| B | GLY9 |
| B | GLY11 |
| B | ARG12 |
| B | ILE13 |
| B | ASN33 |
| B | ASP34 |
| B | ARG78 |
| B | SER96 |
| B | THR97 |
| B | GLY98 |
| B | LEU99 |
| B | THR120 |
| B | CYS150 |
| B | ALA181 |
| B | ASN314 |
| B | TYR318 |
| B | HOH525 |
| B | HOH566 |
| B | HOH598 |
| B | HOH609 |
| B | HOH610 |
| B | HOH616 |
| B | HOH660 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue MG B 401 |
| Chain | Residue |
| B | ALA21 |
| B | ARG24 |
| B | ILE27 |
| site_id | AC5 |
| Number of Residues | 28 |
| Details | binding site for residue NAD C 400 |
| Chain | Residue |
| C | ASN8 |
| C | GLY9 |
| C | PHE10 |
| C | GLY11 |
| C | ARG12 |
| C | ILE13 |
| C | ASN33 |
| C | ASP34 |
| C | ARG78 |
| C | SER96 |
| C | THR97 |
| C | GLY98 |
| C | LEU99 |
| C | THR120 |
| C | CYS150 |
| C | ALA181 |
| C | ASN314 |
| C | TYR318 |
| C | HOH538 |
| C | HOH569 |
| C | HOH641 |
| C | HOH642 |
| C | HOH651 |
| C | HOH657 |
| C | HOH674 |
| C | HOH680 |
| C | HOH681 |
| D | PRO189 |
| site_id | AC6 |
| Number of Residues | 27 |
| Details | binding site for residue NAD D 400 |
| Chain | Residue |
| D | THR120 |
| D | CYS150 |
| D | ALA181 |
| D | ASN314 |
| D | HOH515 |
| D | HOH522 |
| D | HOH546 |
| D | HOH559 |
| D | HOH597 |
| D | HOH619 |
| D | HOH625 |
| D | HOH626 |
| D | HOH658 |
| D | HOH666 |
| C | PRO189 |
| D | ASN8 |
| D | GLY9 |
| D | GLY11 |
| D | ARG12 |
| D | ILE13 |
| D | ASN33 |
| D | ASP34 |
| D | ARG78 |
| D | SER96 |
| D | THR97 |
| D | GLY98 |
| D | LEU99 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue MG D 401 |
| Chain | Residue |
| D | ALA21 |
| D | ARG24 |
| D | ILE27 |
Functional Information from PROSITE/UniProt
| site_id | PS00071 |
| Number of Residues | 8 |
| Details | GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTNcL |
| Chain | Residue | Details |
| A | ALA148-LEU155 |
