4P4L
Crystal Structure of Mycobacterium tuberculosis Shikimate Dehydrogenase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004764 | molecular_function | shikimate 3-dehydrogenase (NADP+) activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0009423 | biological_process | chorismate biosynthetic process |
| A | 0019632 | biological_process | shikimate metabolic process |
| A | 0050661 | molecular_function | NADP binding |
| B | 0004764 | molecular_function | shikimate 3-dehydrogenase (NADP+) activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0009423 | biological_process | chorismate biosynthetic process |
| B | 0019632 | biological_process | shikimate metabolic process |
| B | 0050661 | molecular_function | NADP binding |
| C | 0004764 | molecular_function | shikimate 3-dehydrogenase (NADP+) activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| C | 0009423 | biological_process | chorismate biosynthetic process |
| C | 0019632 | biological_process | shikimate metabolic process |
| C | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue SKM A 301 |
| Chain | Residue |
| A | SER18 |
| A | GLN247 |
| A | HOH418 |
| A | SER20 |
| A | THR65 |
| A | LYS69 |
| A | ASN90 |
| A | ASP105 |
| A | TYR215 |
| A | LEU240 |
| A | GLN243 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 302 |
| Chain | Residue |
| A | LYS7 |
| A | GLY56 |
| A | TRP59 |
| A | HOH431 |
| B | ARG74 |
| B | HOH403 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 303 |
| Chain | Residue |
| A | GLY124 |
| A | SER125 |
| A | ALA148 |
| A | ARG149 |
| A | ASN150 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | binding site for residue SKM B 301 |
| Chain | Residue |
| B | VAL10 |
| B | SER18 |
| B | SER20 |
| B | THR65 |
| B | LYS69 |
| B | ASN90 |
| B | ASP105 |
| B | TYR215 |
| B | LEU240 |
| B | GLN243 |
| B | GLN247 |
| B | HOH417 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 302 |
| Chain | Residue |
| B | GLY124 |
| B | SER125 |
| B | ALA148 |
| B | ARG149 |
| B | ASN150 |
| B | HOH418 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for residue SKM C 301 |
| Chain | Residue |
| C | SER18 |
| C | SER20 |
| C | THR65 |
| C | LYS69 |
| C | ASN90 |
| C | ASP105 |
| C | GLN243 |
| C | GLN247 |
| C | HOH436 |
| C | HOH445 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 C 302 |
| Chain | Residue |
| A | ALA45 |
| A | ARG74 |
| A | HOH405 |
| C | LYS7 |
| C | GLY54 |
| C | GLY56 |
| C | TRP59 |
| C | HOH438 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 C 303 |
| Chain | Residue |
| C | GLY124 |
| C | SER125 |
| C | ALA148 |
| C | ARG149 |
| C | ASN150 |
