Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0001726 | cellular_component | ruffle |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005523 | molecular_function | tropomyosin binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005635 | cellular_component | nuclear envelope |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| B | 0015075 | molecular_function | monoatomic ion transmembrane transporter activity |
| B | 0031012 | cellular_component | extracellular matrix |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0044548 | molecular_function | S100 protein binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0048306 | molecular_function | calcium-dependent protein binding |
| B | 0048471 | cellular_component | perinuclear region of cytoplasm |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue ZN A 1001 |
| Chain | Residue |
| A | ASP128 |
| A | HIS180 |
| A | GLU182 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1002 |
| Chain | Residue |
| A | ASP160 |
| A | ASP201 |
| A | CL1007 |
| A | CL1008 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1003 |
| Chain | Residue |
| A | HOH1144 |
| A | HOH1147 |
| A | GLU32 |
| A | HIS217 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue ZN A 1004 |
| Chain | Residue |
| A | HIS270 |
| A | CL1009 |
| A | HOH1105 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 1006 |
| Chain | Residue |
| A | GLU132 |
| A | ARG228 |
| B | HIS17 |
| B | HIS27 |
| B | ZN101 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 1007 |
| Chain | Residue |
| A | ASP160 |
| A | ASP201 |
| A | ZN1002 |
| A | CL1008 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 1008 |
| Chain | Residue |
| A | ASP160 |
| A | ASP201 |
| A | ZN1002 |
| A | CL1007 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 1009 |
| Chain | Residue |
| A | HIS270 |
| A | ZN1004 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 1010 |
| Chain | Residue |
| A | THR55 |
| A | ARG57 |
| A | TRP72 |
| A | ASP93 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 1011 |
| Chain | Residue |
| A | ASP73 |
| A | HOH1101 |
| B | ASP65 |
| B | GLN66 |
| B | GLU67 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue ACT A 1012 |
| Chain | Residue |
| A | ARG77 |
| A | HOH1102 |
| A | HOH1105 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 1013 |
| Chain | Residue |
| A | ARG228 |
| A | HOH1249 |
| B | ASN69 |
| B | GLN71 |
| B | HOH218 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 1014 |
| Chain | Residue |
| A | THR154 |
| A | LEU155 |
| A | GLU175 |
| A | HOH1251 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 101 |
| Chain | Residue |
| A | GLU132 |
| A | CL1006 |
| B | HIS17 |
| B | HIS27 |
| site_id | AD6 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 102 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 103 |
| Chain | Residue |
| B | ASP61 |
| B | ASN63 |
| B | ASP65 |
| B | GLU67 |
| B | GLU72 |
| B | HOH223 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 104 |
| Chain | Residue |
| B | SER20 |
| B | GLU23 |
| B | ASP25 |
| B | THR28 |
| B | GLU33 |
| B | HOH209 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 105 |
| Chain | Residue |
| B | CYS3 |
| B | ARG55 |
| B | ASP59 |
| B | HOH208 |
| site_id | AE1 |
| Number of Residues | 1 |
| Details | binding site for residue ACT B 106 |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DRNKDQEVNfqEY |
| Chain | Residue | Details |
| B | ASP61-TYR73 | |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCVATH |
| Chain | Residue | Details |
| A | TYR299-HIS305 | |
| site_id | PS00303 |
| Number of Residues | 22 |
| Details | S100_CABP S-100/ICaBP type calcium binding protein signature. LMddLDrnkDqevNFqEYvaFL |
| Chain | Residue | Details |
| B | LEU56-LEU77 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 93 |
| Details | Domain: {"description":"Ig-like V-type"} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 97 |
| Details | Domain: {"description":"Ig-like C2-type 1"} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 90 |
| Details | Domain: {"description":"Ig-like C2-type 2"} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 35 |
| Details | Domain: {"description":"EF-hand 1","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 35 |
| Details | Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI8 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P06703","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P06703","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]} |
