4OUG

Crystal structure of the ternary complex of camel peptidoglycan recognition protein, PGRP-S with lipopolysaccharide and palmitic acid at 2.46 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001818	biological_process	negative regulation of cytokine production
A	0002376	biological_process	immune system process
A	0005576	cellular_component	extracellular region
A	0008270	molecular_function	zinc ion binding
A	0008745	molecular_function	N-acetylmuramoyl-L-alanine amidase activity
A	0009253	biological_process	peptidoglycan catabolic process
A	0016019	molecular_function	peptidoglycan immune receptor activity
A	0016045	biological_process	detection of bacterium
A	0042742	biological_process	defense response to bacterium
A	0042834	molecular_function	peptidoglycan binding
A	0045087	biological_process	innate immune response
A	0050830	biological_process	defense response to Gram-positive bacterium
B	0001818	biological_process	negative regulation of cytokine production
B	0002376	biological_process	immune system process
B	0005576	cellular_component	extracellular region
B	0008270	molecular_function	zinc ion binding
B	0008745	molecular_function	N-acetylmuramoyl-L-alanine amidase activity
B	0009253	biological_process	peptidoglycan catabolic process
B	0016019	molecular_function	peptidoglycan immune receptor activity
B	0016045	biological_process	detection of bacterium
B	0042742	biological_process	defense response to bacterium
B	0042834	molecular_function	peptidoglycan binding
B	0045087	biological_process	innate immune response
B	0050830	biological_process	defense response to Gram-positive bacterium
C	0001818	biological_process	negative regulation of cytokine production
C	0002376	biological_process	immune system process
C	0005576	cellular_component	extracellular region
C	0008270	molecular_function	zinc ion binding
C	0008745	molecular_function	N-acetylmuramoyl-L-alanine amidase activity
C	0009253	biological_process	peptidoglycan catabolic process
C	0016019	molecular_function	peptidoglycan immune receptor activity
C	0016045	biological_process	detection of bacterium
C	0042742	biological_process	defense response to bacterium
C	0042834	molecular_function	peptidoglycan binding
C	0045087	biological_process	innate immune response
C	0050830	biological_process	defense response to Gram-positive bacterium
D	0001818	biological_process	negative regulation of cytokine production
D	0002376	biological_process	immune system process
D	0005576	cellular_component	extracellular region
D	0008270	molecular_function	zinc ion binding
D	0008745	molecular_function	N-acetylmuramoyl-L-alanine amidase activity
D	0009253	biological_process	peptidoglycan catabolic process
D	0016019	molecular_function	peptidoglycan immune receptor activity
D	0016045	biological_process	detection of bacterium
D	0042742	biological_process	defense response to bacterium
D	0042834	molecular_function	peptidoglycan binding
D	0045087	biological_process	innate immune response
D	0050830	biological_process	defense response to Gram-positive bacterium

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PLM B 201

Chain	Residue
A	ALA5
A	CYS6
B	PRO4
B	ALA129
B	HOH379
D	ARG31
D	ARG138

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site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TLA C 201

Chain	Residue
C	THR152
C	LEU153
C	SER154
C	GOL202
C	HOH376
D	HIS37
D	ALA39
D	THR152
D	LEU153
D	SER154
C	HIS37
C	ALA39

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL C 202

Chain	Residue
C	PRO151
C	THR152
C	TLA201
D	HIS37
D	THR38
D	TYR71
D	HIS146

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site_id	AC4
Number of Residues	25
Details	BINDING SITE FOR RESIDUE LP5 C 203

Chain	Residue
A	SER139
A	GLU142
C	LEU64
C	TRP66
C	LYS90
C	GLY91
C	ALA92
C	HIS93
C	ALA94
C	GLY95
C	PRO96
C	ASN99
C	GLN150
C	HOH344
D	GLY95
D	PRO96
D	THR97
D	TRP98
D	ASN99
D	LYS144
D	HIS146
D	ASP148
D	VAL149
D	GLN150
D	PRO151

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	512
Details	Domain: {"description":"N-acetylmuramoyl-L-alanine amidase","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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