4OTL
X-ray Crystal Structure of Serine Hydroxymethyl Transferase from Burkholderia cenocepacia bound to PLP and Glycine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006545 | biological_process | glycine biosynthetic process |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019264 | biological_process | glycine biosynthetic process from serine |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0035999 | biological_process | tetrahydrofolate interconversion |
| B | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006545 | biological_process | glycine biosynthetic process |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0019264 | biological_process | glycine biosynthetic process from serine |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0035999 | biological_process | tetrahydrofolate interconversion |
| C | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006545 | biological_process | glycine biosynthetic process |
| C | 0006730 | biological_process | one-carbon metabolic process |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0019264 | biological_process | glycine biosynthetic process from serine |
| C | 0030170 | molecular_function | pyridoxal phosphate binding |
| C | 0035999 | biological_process | tetrahydrofolate interconversion |
| D | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006545 | biological_process | glycine biosynthetic process |
| D | 0006730 | biological_process | one-carbon metabolic process |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0019264 | biological_process | glycine biosynthetic process from serine |
| D | 0030170 | molecular_function | pyridoxal phosphate binding |
| D | 0035999 | biological_process | tetrahydrofolate interconversion |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE PLP A 500 |
| Chain | Residue |
| A | SER98 |
| A | HIS229 |
| A | LYS230 |
| A | GLY501 |
| C | TYR56 |
| C | GLY260 |
| C | GLY261 |
| C | HOH839 |
| A | GLY99 |
| A | SER100 |
| A | HIS127 |
| A | SER176 |
| A | ASP201 |
| A | ALA203 |
| A | HIS204 |
| A | THR227 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GLY A 501 |
| Chain | Residue |
| A | SER36 |
| A | HIS127 |
| A | HIS204 |
| A | LYS230 |
| A | ARG361 |
| A | PLP500 |
| C | TYR66 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE PLP B 501 |
| Chain | Residue |
| B | SER98 |
| B | GLY99 |
| B | SER100 |
| B | HIS127 |
| B | ALA175 |
| B | SER176 |
| B | ASP201 |
| B | HIS204 |
| B | THR227 |
| B | HIS229 |
| B | LYS230 |
| B | GLY502 |
| B | HOH649 |
| D | TYR56 |
| D | GLY260 |
| D | GLY261 |
| D | HOH928 |
| D | HOH964 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GLY B 502 |
| Chain | Residue |
| B | SER36 |
| B | HIS204 |
| B | LYS230 |
| B | ARG361 |
| B | PLP501 |
| D | TYR56 |
| D | TYR66 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 503 |
| Chain | Residue |
| B | ALA109 |
| B | MET110 |
| B | TYR197 |
| site_id | AC6 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE PLP C 700 |
| Chain | Residue |
| A | TYR56 |
| A | GLY260 |
| A | GLY261 |
| A | HOH641 |
| A | HOH684 |
| C | SER98 |
| C | GLY99 |
| C | SER100 |
| C | HIS127 |
| C | ALA175 |
| C | SER176 |
| C | ASP201 |
| C | ALA203 |
| C | HIS204 |
| C | THR227 |
| C | HIS229 |
| C | LYS230 |
| C | GLY701 |
| C | HOH840 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GLY C 701 |
| Chain | Residue |
| A | TYR56 |
| A | TYR66 |
| A | HOH674 |
| C | SER36 |
| C | HIS127 |
| C | HIS204 |
| C | LYS230 |
| C | ARG361 |
| C | PLP700 |
| site_id | AC8 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE PLP D 800 |
| Chain | Residue |
| B | TYR56 |
| B | GLY260 |
| B | GLY261 |
| D | SER98 |
| D | GLY99 |
| D | SER100 |
| D | HIS127 |
| D | ALA175 |
| D | SER176 |
| D | ASP201 |
| D | HIS204 |
| D | THR227 |
| D | HIS229 |
| D | LYS230 |
| D | GLY801 |
| D | HOH954 |
| D | HOH955 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GLY D 801 |
| Chain | Residue |
| D | HIS204 |
| D | LYS230 |
| D | ARG361 |
| D | PLP800 |
| B | TYR56 |
| B | TYR66 |
| D | SER36 |
Functional Information from PROSITE/UniProt
| site_id | PS00096 |
| Number of Residues | 17 |
| Details | SHMT Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. DFvTTTTHKSLrGPRGG |
| Chain | Residue | Details |
| A | ASP222-GLY238 |
