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4OT9

crystal structure of the C-terminal domain of p100/NF-kB2

Functional Information from GO Data
ChainGOidnamespacecontents
A0003700molecular_functionDNA-binding transcription factor activity
A0005737cellular_componentcytoplasm
A0006355biological_processregulation of transcription, DNA-templated
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 801
ChainResidue
AARG611
AARG685
ALYS741

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 802
ChainResidue
AARG635
ATHR665
AALA667
AASN669

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Cleavage (when cotranslationally processed)
ChainResidueDetails
AALA460

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: Breakpoint for translocation to form NFKB2-IGHA1 oncogene
ChainResidueDetails
AILE496

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648
ChainResidueDetails
AGLN435

site_idSWS_FT_FI4
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:8887665
ChainResidueDetails
AGLY719
AGLU721
AASP723

226707

PDB entries from 2024-10-30

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