4OT8

X-ray Crystal Structure of Serine Hydroxymethyl Transferase from Burkholderia cenocepacia bound to PLP and Serine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004372	molecular_function	glycine hydroxymethyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006545	biological_process	glycine biosynthetic process
A	0006565	biological_process	L-serine catabolic process
A	0006730	biological_process	one-carbon metabolic process
A	0008270	molecular_function	zinc ion binding
A	0008652	biological_process	amino acid biosynthetic process
A	0016740	molecular_function	transferase activity
A	0019264	biological_process	glycine biosynthetic process from serine
A	0030170	molecular_function	pyridoxal phosphate binding
A	0035999	biological_process	tetrahydrofolate interconversion
A	0046653	biological_process	tetrahydrofolate metabolic process
A	0046655	biological_process	folic acid metabolic process
A	0050897	molecular_function	cobalt ion binding
A	0070905	molecular_function	serine binding
B	0004372	molecular_function	glycine hydroxymethyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006545	biological_process	glycine biosynthetic process
B	0006565	biological_process	L-serine catabolic process
B	0006730	biological_process	one-carbon metabolic process
B	0008270	molecular_function	zinc ion binding
B	0008652	biological_process	amino acid biosynthetic process
B	0016740	molecular_function	transferase activity
B	0019264	biological_process	glycine biosynthetic process from serine
B	0030170	molecular_function	pyridoxal phosphate binding
B	0035999	biological_process	tetrahydrofolate interconversion
B	0046653	biological_process	tetrahydrofolate metabolic process
B	0046655	biological_process	folic acid metabolic process
B	0050897	molecular_function	cobalt ion binding
B	0070905	molecular_function	serine binding
C	0004372	molecular_function	glycine hydroxymethyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006545	biological_process	glycine biosynthetic process
C	0006565	biological_process	L-serine catabolic process
C	0006730	biological_process	one-carbon metabolic process
C	0008270	molecular_function	zinc ion binding
C	0008652	biological_process	amino acid biosynthetic process
C	0016740	molecular_function	transferase activity
C	0019264	biological_process	glycine biosynthetic process from serine
C	0030170	molecular_function	pyridoxal phosphate binding
C	0035999	biological_process	tetrahydrofolate interconversion
C	0046653	biological_process	tetrahydrofolate metabolic process
C	0046655	biological_process	folic acid metabolic process
C	0050897	molecular_function	cobalt ion binding
C	0070905	molecular_function	serine binding
D	0004372	molecular_function	glycine hydroxymethyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006545	biological_process	glycine biosynthetic process
D	0006565	biological_process	L-serine catabolic process
D	0006730	biological_process	one-carbon metabolic process
D	0008270	molecular_function	zinc ion binding
D	0008652	biological_process	amino acid biosynthetic process
D	0016740	molecular_function	transferase activity
D	0019264	biological_process	glycine biosynthetic process from serine
D	0030170	molecular_function	pyridoxal phosphate binding
D	0035999	biological_process	tetrahydrofolate interconversion
D	0046653	biological_process	tetrahydrofolate metabolic process
D	0046655	biological_process	folic acid metabolic process
D	0050897	molecular_function	cobalt ion binding
D	0070905	molecular_function	serine binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE PLP A 501

Chain	Residue
A	SER98
A	LYS230
A	SER502
A	HOH763
C	TYR56
C	GLY260
C	GLY261
C	HOH804
A	GLY99
A	SER100
A	HIS127
A	SER176
A	ASP201
A	HIS204
A	THR227
A	HIS229

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SER A 502

Chain	Residue
A	SER36
A	HIS127
A	HIS204
A	LYS230
A	ARG361
A	PLP501
C	TYR56
C	GLU58
C	TYR66

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SER A 503

Chain	Residue
A	TYR56
A	GLU58
A	TYR66
C	SER36
C	HIS127
C	HIS204
C	LYS230
C	ARG361
C	PLP700

---

site_id	AC4
Number of Residues	18
Details	BINDING SITE FOR RESIDUE PLP B 501

Chain	Residue
B	SER98
B	GLY99
B	SER100
B	HIS127
B	SER176
B	ASP201
B	ALA203
B	HIS204
B	THR227
B	HIS229
B	LYS230
B	SER502
B	HOH760
D	TYR56
D	GLY260
D	GLY261
D	HOH938
D	HOH1004

---

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SER B 502

Chain	Residue
B	SER36
B	HIS127
B	SER176
B	HIS204
B	LYS230
B	ARG361
B	PLP501
D	GLU58
D	TYR66

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SER B 503

Chain	Residue
B	TYR56
B	GLU58
B	TYR66
D	SER36
D	HIS127
D	HIS204
D	ARG361
D	PLP800

---

site_id	AC7
Number of Residues	18
Details	BINDING SITE FOR RESIDUE PLP C 700

Chain	Residue
A	TYR56
A	GLY260
A	GLY261
A	SER503
A	HOH642
C	SER98
C	GLY99
C	SER100
C	HIS127
C	ALA175
C	SER176
C	ASP201
C	ALA203
C	HIS204
C	THR227
C	HIS229
C	LYS230
C	HOH894

---

site_id	AC8
Number of Residues	17
Details	BINDING SITE FOR RESIDUE PLP D 800

Chain	Residue
D	HIS204
D	THR227
D	HIS229
D	LYS230
D	HOH1002
B	TYR56
B	GLY260
B	GLY261
B	SER503
B	HOH672
D	SER98
D	GLY99
D	SER100
D	HIS127
D	ALA175
D	SER176
D	ASP201

---

Functional Information from PROSITE/UniProt

site_id	PS00096
Number of Residues	17
Details	SHMT Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. DFvTTTTHKSLrGPRGG

Chain	Residue	Details
A	ASP222-GLY238

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