4OT8
X-ray Crystal Structure of Serine Hydroxymethyl Transferase from Burkholderia cenocepacia bound to PLP and Serine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006545 | biological_process | glycine biosynthetic process |
| A | 0019264 | biological_process | obsolete glycine biosynthetic process from L-serine |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0035999 | biological_process | tetrahydrofolate interconversion |
| A | 0046653 | biological_process | tetrahydrofolate metabolic process |
| B | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006545 | biological_process | glycine biosynthetic process |
| B | 0019264 | biological_process | obsolete glycine biosynthetic process from L-serine |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0035999 | biological_process | tetrahydrofolate interconversion |
| B | 0046653 | biological_process | tetrahydrofolate metabolic process |
| C | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006545 | biological_process | glycine biosynthetic process |
| C | 0019264 | biological_process | obsolete glycine biosynthetic process from L-serine |
| C | 0030170 | molecular_function | pyridoxal phosphate binding |
| C | 0035999 | biological_process | tetrahydrofolate interconversion |
| C | 0046653 | biological_process | tetrahydrofolate metabolic process |
| D | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006545 | biological_process | glycine biosynthetic process |
| D | 0019264 | biological_process | obsolete glycine biosynthetic process from L-serine |
| D | 0030170 | molecular_function | pyridoxal phosphate binding |
| D | 0035999 | biological_process | tetrahydrofolate interconversion |
| D | 0046653 | biological_process | tetrahydrofolate metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE PLP A 501 |
| Chain | Residue |
| A | SER98 |
| A | LYS230 |
| A | SER502 |
| A | HOH763 |
| C | TYR56 |
| C | GLY260 |
| C | GLY261 |
| C | HOH804 |
| A | GLY99 |
| A | SER100 |
| A | HIS127 |
| A | SER176 |
| A | ASP201 |
| A | HIS204 |
| A | THR227 |
| A | HIS229 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SER A 502 |
| Chain | Residue |
| A | SER36 |
| A | HIS127 |
| A | HIS204 |
| A | LYS230 |
| A | ARG361 |
| A | PLP501 |
| C | TYR56 |
| C | GLU58 |
| C | TYR66 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SER A 503 |
| Chain | Residue |
| A | TYR56 |
| A | GLU58 |
| A | TYR66 |
| C | SER36 |
| C | HIS127 |
| C | HIS204 |
| C | LYS230 |
| C | ARG361 |
| C | PLP700 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE PLP B 501 |
| Chain | Residue |
| B | SER98 |
| B | GLY99 |
| B | SER100 |
| B | HIS127 |
| B | SER176 |
| B | ASP201 |
| B | ALA203 |
| B | HIS204 |
| B | THR227 |
| B | HIS229 |
| B | LYS230 |
| B | SER502 |
| B | HOH760 |
| D | TYR56 |
| D | GLY260 |
| D | GLY261 |
| D | HOH938 |
| D | HOH1004 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SER B 502 |
| Chain | Residue |
| B | SER36 |
| B | HIS127 |
| B | SER176 |
| B | HIS204 |
| B | LYS230 |
| B | ARG361 |
| B | PLP501 |
| D | GLU58 |
| D | TYR66 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SER B 503 |
| Chain | Residue |
| B | TYR56 |
| B | GLU58 |
| B | TYR66 |
| D | SER36 |
| D | HIS127 |
| D | HIS204 |
| D | ARG361 |
| D | PLP800 |
| site_id | AC7 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE PLP C 700 |
| Chain | Residue |
| A | TYR56 |
| A | GLY260 |
| A | GLY261 |
| A | SER503 |
| A | HOH642 |
| C | SER98 |
| C | GLY99 |
| C | SER100 |
| C | HIS127 |
| C | ALA175 |
| C | SER176 |
| C | ASP201 |
| C | ALA203 |
| C | HIS204 |
| C | THR227 |
| C | HIS229 |
| C | LYS230 |
| C | HOH894 |
| site_id | AC8 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE PLP D 800 |
| Chain | Residue |
| D | HIS204 |
| D | THR227 |
| D | HIS229 |
| D | LYS230 |
| D | HOH1002 |
| B | TYR56 |
| B | GLY260 |
| B | GLY261 |
| B | SER503 |
| B | HOH672 |
| D | SER98 |
| D | GLY99 |
| D | SER100 |
| D | HIS127 |
| D | ALA175 |
| D | SER176 |
| D | ASP201 |
Functional Information from PROSITE/UniProt
| site_id | PS00096 |
| Number of Residues | 17 |
| Details | SHMT Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. DFvTTTTHKSLrGPRGG |
| Chain | Residue | Details |
| A | ASP222-GLY238 |
