4OT8
X-ray Crystal Structure of Serine Hydroxymethyl Transferase from Burkholderia cenocepacia bound to PLP and Serine
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0006545 | biological_process | glycine biosynthetic process |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0008652 | biological_process | amino acid biosynthetic process |
A | 0016740 | molecular_function | transferase activity |
A | 0019264 | biological_process | glycine biosynthetic process from serine |
A | 0030170 | molecular_function | pyridoxal phosphate binding |
A | 0035999 | biological_process | tetrahydrofolate interconversion |
B | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0006545 | biological_process | glycine biosynthetic process |
B | 0006730 | biological_process | one-carbon metabolic process |
B | 0008652 | biological_process | amino acid biosynthetic process |
B | 0016740 | molecular_function | transferase activity |
B | 0019264 | biological_process | glycine biosynthetic process from serine |
B | 0030170 | molecular_function | pyridoxal phosphate binding |
B | 0035999 | biological_process | tetrahydrofolate interconversion |
C | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0006545 | biological_process | glycine biosynthetic process |
C | 0006730 | biological_process | one-carbon metabolic process |
C | 0008652 | biological_process | amino acid biosynthetic process |
C | 0016740 | molecular_function | transferase activity |
C | 0019264 | biological_process | glycine biosynthetic process from serine |
C | 0030170 | molecular_function | pyridoxal phosphate binding |
C | 0035999 | biological_process | tetrahydrofolate interconversion |
D | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0006545 | biological_process | glycine biosynthetic process |
D | 0006730 | biological_process | one-carbon metabolic process |
D | 0008652 | biological_process | amino acid biosynthetic process |
D | 0016740 | molecular_function | transferase activity |
D | 0019264 | biological_process | glycine biosynthetic process from serine |
D | 0030170 | molecular_function | pyridoxal phosphate binding |
D | 0035999 | biological_process | tetrahydrofolate interconversion |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE PLP A 501 |
Chain | Residue |
A | SER98 |
A | LYS230 |
A | SER502 |
A | HOH763 |
C | TYR56 |
C | GLY260 |
C | GLY261 |
C | HOH804 |
A | GLY99 |
A | SER100 |
A | HIS127 |
A | SER176 |
A | ASP201 |
A | HIS204 |
A | THR227 |
A | HIS229 |
site_id | AC2 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE SER A 502 |
Chain | Residue |
A | SER36 |
A | HIS127 |
A | HIS204 |
A | LYS230 |
A | ARG361 |
A | PLP501 |
C | TYR56 |
C | GLU58 |
C | TYR66 |
site_id | AC3 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE SER A 503 |
Chain | Residue |
A | TYR56 |
A | GLU58 |
A | TYR66 |
C | SER36 |
C | HIS127 |
C | HIS204 |
C | LYS230 |
C | ARG361 |
C | PLP700 |
site_id | AC4 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE PLP B 501 |
Chain | Residue |
B | SER98 |
B | GLY99 |
B | SER100 |
B | HIS127 |
B | SER176 |
B | ASP201 |
B | ALA203 |
B | HIS204 |
B | THR227 |
B | HIS229 |
B | LYS230 |
B | SER502 |
B | HOH760 |
D | TYR56 |
D | GLY260 |
D | GLY261 |
D | HOH938 |
D | HOH1004 |
site_id | AC5 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE SER B 502 |
Chain | Residue |
B | SER36 |
B | HIS127 |
B | SER176 |
B | HIS204 |
B | LYS230 |
B | ARG361 |
B | PLP501 |
D | GLU58 |
D | TYR66 |
site_id | AC6 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SER B 503 |
Chain | Residue |
B | TYR56 |
B | GLU58 |
B | TYR66 |
D | SER36 |
D | HIS127 |
D | HIS204 |
D | ARG361 |
D | PLP800 |
site_id | AC7 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE PLP C 700 |
Chain | Residue |
A | TYR56 |
A | GLY260 |
A | GLY261 |
A | SER503 |
A | HOH642 |
C | SER98 |
C | GLY99 |
C | SER100 |
C | HIS127 |
C | ALA175 |
C | SER176 |
C | ASP201 |
C | ALA203 |
C | HIS204 |
C | THR227 |
C | HIS229 |
C | LYS230 |
C | HOH894 |
site_id | AC8 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE PLP D 800 |
Chain | Residue |
D | HIS204 |
D | THR227 |
D | HIS229 |
D | LYS230 |
D | HOH1002 |
B | TYR56 |
B | GLY260 |
B | GLY261 |
B | SER503 |
B | HOH672 |
D | SER98 |
D | GLY99 |
D | SER100 |
D | HIS127 |
D | ALA175 |
D | SER176 |
D | ASP201 |
Functional Information from PROSITE/UniProt
site_id | PS00096 |
Number of Residues | 17 |
Details | SHMT Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. DFvTTTTHKSLrGPRGG |
Chain | Residue | Details |
A | ASP222-GLY238 |