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4OSO

The crystal structure of landomycin C-6 ketoreductase LanV with bound NADP and rabelomycin

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0016491molecular_functionoxidoreductase activity
B0000166molecular_functionnucleotide binding
B0016491molecular_functionoxidoreductase activity
Functional Information from PDB Data
site_idAC1
Number of Residues28
DetailsBINDING SITE FOR RESIDUE NAP A 301
ChainResidue
AGLY13
AGLY40
AALA63
ALEU65
AASN97
AALA98
AGLY99
AMET101
AARG116
AVAL120
AVAL145
ASER15
ASER146
ATYR160
ALYS164
APRO190
AGLY191
ATHR193
AASN195
A2V4302
AHOH435
AARG16
AGLY17
AILE18
AHIS36
ATYR37
AALA38
ATHR39

site_idAC2
Number of Residues11
DetailsBINDING SITE FOR RESIDUE 2V4 A 302
ChainResidue
AMET101
ASER147
AGLY148
ALEU149
ATYR160
APRO190
AGLY191
ALEU209
ALEU212
ATHR250
ANAP301

site_idAC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE PEG A 303
ChainResidue
AMET136
AHOH452

site_idAC4
Number of Residues27
DetailsBINDING SITE FOR RESIDUE NAP B 301
ChainResidue
BGLY13
BSER15
BARG16
BGLY17
BILE18
BHIS36
BALA38
BTHR39
BGLY40
BALA63
BLEU65
BASN97
BVAL100
BMET101
BARG116
BVAL120
BVAL145
BSER146
BTYR160
BLYS164
BPRO190
BGLY191
BTHR193
BASN195
B2V4302
BHOH431
BHOH443

site_idAC5
Number of Residues13
DetailsBINDING SITE FOR RESIDUE 2V4 B 302
ChainResidue
BMET101
BMET103
BSER147
BGLY148
BLEU149
BGLN157
BTYR160
BPRO190
BGLY191
BLEU209
BLEU212
BTHR250
BNAP301

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PEG B 303
ChainResidue
BASP90
BSER134
BHOH419

Functional Information from PROSITE/UniProt
site_idPS00061
Number of Residues29
DetailsADH_SHORT Short-chain dehydrogenases/reductases family signature. SgltrvaspdQvtYGMSKGALeQIAlHFS
ChainResidueDetails
ASER147-SER175

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PDB entries from 2024-11-06

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