4ONC

Crystal Structure of Mycobacterium Tuberculosis Decaprenyl Diphosphate Synthase in Complex with BPH-640

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004659	molecular_function	prenyltransferase activity
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0008834	molecular_function	ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] activity
A	0016094	biological_process	polyprenol biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
A	0030145	molecular_function	manganese ion binding
A	0033850	molecular_function	Z-farnesyl diphosphate synthase activity
A	0045547	molecular_function	ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity
A	0046872	molecular_function	metal ion binding
A	0052923	molecular_function	all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity
B	0000287	molecular_function	magnesium ion binding
B	0004659	molecular_function	prenyltransferase activity
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0008834	molecular_function	ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] activity
B	0016094	biological_process	polyprenol biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
B	0030145	molecular_function	manganese ion binding
B	0033850	molecular_function	Z-farnesyl diphosphate synthase activity
B	0045547	molecular_function	ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity
B	0046872	molecular_function	metal ion binding
B	0052923	molecular_function	all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 40B A 500

Chain	Residue
A	GLY77
B	ASN172
B	GLU173
B	VAL176
B	ARG292
B	PHE293
A	GLY79
A	ARG80
A	THR83
A	ARG89
A	ARG127
A	HOH679
A	HOH809
B	ARG144

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site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 40B B 500

Chain	Residue
B	GLY77
B	ASN78
B	GLY79
B	ARG80
B	ARG89
B	ASN124
B	ARG127
B	HOH722
B	HOH781
B	HOH804
B	HOH810

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Functional Information from PROSITE/UniProt

site_id	PS01066
Number of Residues	18
Details	UPP_SYNTHASE Undecaprenyl pyrophosphate synthase family signature. DLFLRTSGeqRsSnFMLW

Chain	Residue	Details
A	ASP240-TRP257

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	28
Details	Binding site: {}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	10
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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