4ON3
Crystal structure of human sorting nexin 10 (SNX10)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005545 | molecular_function | 1-phosphatidylinositol binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005768 | cellular_component | endosome |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005813 | cellular_component | centrosome |
| A | 0005829 | cellular_component | cytosol |
| A | 0006886 | biological_process | intracellular protein transport |
| A | 0007032 | biological_process | endosome organization |
| A | 0008289 | molecular_function | lipid binding |
| A | 0010008 | cellular_component | endosome membrane |
| A | 0015031 | biological_process | protein transport |
| A | 0015630 | cellular_component | microtubule cytoskeleton |
| A | 0016050 | biological_process | vesicle organization |
| A | 0030030 | biological_process | cell projection organization |
| A | 0030141 | cellular_component | secretory granule |
| A | 0030316 | biological_process | osteoclast differentiation |
| A | 0031313 | cellular_component | extrinsic component of endosome membrane |
| A | 0035091 | molecular_function | phosphatidylinositol binding |
| A | 0051117 | molecular_function | ATPase binding |
| A | 0060271 | biological_process | cilium assembly |
| A | 0061512 | biological_process | protein localization to cilium |
| A | 0071539 | biological_process | protein localization to centrosome |
| A | 0090651 | cellular_component | apical cytoplasm |
| A | 1901981 | molecular_function | phosphatidylinositol phosphate binding |
| B | 0005545 | molecular_function | 1-phosphatidylinositol binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005768 | cellular_component | endosome |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005813 | cellular_component | centrosome |
| B | 0005829 | cellular_component | cytosol |
| B | 0006886 | biological_process | intracellular protein transport |
| B | 0007032 | biological_process | endosome organization |
| B | 0008289 | molecular_function | lipid binding |
| B | 0010008 | cellular_component | endosome membrane |
| B | 0015031 | biological_process | protein transport |
| B | 0015630 | cellular_component | microtubule cytoskeleton |
| B | 0016050 | biological_process | vesicle organization |
| B | 0030030 | biological_process | cell projection organization |
| B | 0030141 | cellular_component | secretory granule |
| B | 0030316 | biological_process | osteoclast differentiation |
| B | 0031313 | cellular_component | extrinsic component of endosome membrane |
| B | 0035091 | molecular_function | phosphatidylinositol binding |
| B | 0051117 | molecular_function | ATPase binding |
| B | 0060271 | biological_process | cilium assembly |
| B | 0061512 | biological_process | protein localization to cilium |
| B | 0071539 | biological_process | protein localization to centrosome |
| B | 0090651 | cellular_component | apical cytoplasm |
| B | 1901981 | molecular_function | phosphatidylinositol phosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NO3 A 301 |
| Chain | Residue |
| A | ILE30 |
| A | ARG53 |
| A | TYR54 |
| A | ARG55 |
| A | ASN80 |
| A | 1PE308 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NO3 A 302 |
| Chain | Residue |
| A | ASN87 |
| A | HIS90 |
| A | HIS90 |
| A | ASN84 |
| A | ASN84 |
| A | ASN87 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NO3 A 303 |
| Chain | Residue |
| A | LYS22 |
| A | GLU23 |
| A | ASP24 |
| A | PHE25 |
| A | HOH406 |
| A | HOH407 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NO3 A 304 |
| Chain | Residue |
| A | ARG19 |
| A | GLN21 |
| A | ARG51 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NO3 A 305 |
| Chain | Residue |
| A | HIS124 |
| A | TYR140 |
| A | LYS148 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NO3 A 306 |
| Chain | Residue |
| A | VAL50 |
| A | ARG51 |
| A | HIS124 |
| A | PHE149 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NO3 A 307 |
| Chain | Residue |
| A | PHE25 |
| A | ALA68 |
| A | LEU69 |
| A | LEU70 |
| A | LEU110 |
| site_id | AC8 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 1PE A 308 |
| Chain | Residue |
| A | SER28 |
| A | TYR29 |
| A | TYR29 |
| A | ILE30 |
| A | ASN80 |
| A | ASN80 |
| A | LEU81 |
| A | LEU81 |
| A | PHE83 |
| A | PHE83 |
| A | NO3301 |
| A | 1PE312 |
| A | 1PE313 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE 1PE A 309 |
| Chain | Residue |
| A | SER78 |
| A | LYS79 |
| A | PHE82 |
| A | ASN86 |
| A | 1PE311 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 1PE A 310 |
| Chain | Residue |
| A | THR47 |
| A | SER48 |
| A | CYS49 |
| A | ASN153 |
| A | ARG154 |
| B | ARG154 |
| B | PHE156 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE 1PE A 311 |
| Chain | Residue |
| A | TRP26 |
| A | ARG61 |
| A | GLU75 |
| A | LEU76 |
| A | 1PE309 |
| site_id | BC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 1PE A 312 |
| Chain | Residue |
| A | HIS27 |
| A | SER28 |
| A | ARG53 |
| A | ARG55 |
| A | ARG55 |
| A | ASN80 |
| A | 1PE308 |
| A | 1PE313 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 1PE A 313 |
| Chain | Residue |
| A | HIS27 |
| A | SER28 |
| A | LYS79 |
| A | ASN80 |
| A | LEU81 |
| A | 1PE308 |
| A | 1PE312 |
| site_id | BC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NA A 314 |
| Chain | Residue |
| A | ARG61 |
| A | ARG61 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 315 |
| Chain | Residue |
| A | ILE34 |
| A | ILE36 |
| A | SER48 |
| A | LEU121 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 316 |
| Chain | Residue |
| A | VAL11 |
| A | SER12 |
| A | VAL13 |
| A | ARG103 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 317 |
| Chain | Residue |
| A | THR44 |
| A | HIS118 |
| A | GLN122 |
| A | ILE146 |
| site_id | BC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE NO3 B 301 |
| Chain | Residue |
| B | ARG154 |
| A | MET45 |
| A | LYS46 |
| A | THR47 |
| A | ARG154 |
| B | MET45 |
| B | LYS46 |
| B | THR47 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NO3 B 302 |
| Chain | Residue |
| B | ARG53 |
| B | TYR54 |
| B | ARG55 |
| B | NO3303 |
| B | NO3307 |
| B | HOH402 |
| site_id | CC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NO3 B 303 |
| Chain | Residue |
| B | TYR29 |
| B | ILE30 |
| B | PHE83 |
| B | MET85 |
| B | ARG94 |
| B | NO3302 |
| B | HOH402 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NO3 B 304 |
| Chain | Residue |
| B | VAL50 |
| B | ARG51 |
| B | HIS124 |
| B | PHE149 |
| site_id | CC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NO3 B 305 |
| Chain | Residue |
| B | SER141 |
| B | VAL142 |
| B | GLU143 |
| site_id | CC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NO3 B 306 |
| Chain | Residue |
| B | ALA68 |
| B | LEU69 |
| B | LEU70 |
| B | ASN86 |
| B | ARG88 |
| B | LEU110 |
| site_id | CC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NO3 B 307 |
| Chain | Residue |
| B | TYR54 |
| B | ARG55 |
| B | ASN80 |
| B | THR138 |
| B | LYS139 |
| B | TYR140 |
| B | NO3302 |
| site_id | CC7 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 1PE B 308 |
| Chain | Residue |
| A | PHE10 |
| A | ASN39 |
| A | MET41 |
| B | MET41 |
| B | PHE43 |
| B | THR44 |
| B | GLU143 |
| B | GLU144 |
| B | HIS147 |
| B | LYS148 |
| B | HOH411 |
| site_id | CC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE 1PE B 309 |
| Chain | Residue |
| B | ARG61 |
| B | GLU75 |
| B | LEU76 |
| B | LYS139 |
| site_id | CC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE 1PE B 310 |
| Chain | Residue |
| B | ARG16 |
| B | ASP17 |
| B | ARG95 |
| site_id | DC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 1PE B 311 |
| Chain | Residue |
| A | PHE156 |
| B | MET45 |
| B | THR47 |
| B | SER48 |
| B | CYS49 |
| B | GLN122 |
| B | ILE146 |
| B | PHE149 |
| B | ALA150 |
| B | ASN153 |
| B | ARG154 |
| site_id | DC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA B 312 |
| Chain | Residue |
| B | PHE43 |
| B | THR44 |
| B | HIS118 |
| B | GLN122 |
| site_id | DC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA B 313 |
| Chain | Residue |
| B | ILE34 |
| B | ILE36 |
| B | SER48 |
| B | LEU121 |
| site_id | DC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA B 314 |
| Chain | Residue |
| B | ARG55 |
| B | TRP59 |
| B | GLN137 |
| site_id | DC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA B 315 |
| Chain | Residue |
| B | VAL11 |
| B | VAL13 |
| B | ARG103 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 234 |
| Details | Domain: {"description":"PX","evidences":[{"source":"PROSITE-ProRule","id":"PRU00147","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 234 |
| Details | Region: {"description":"Required for interaction with ATP6V1D","evidences":[{"source":"PubMed","id":"21844891","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
