Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0004115 | molecular_function | 3',5'-cyclic-AMP phosphodiesterase activity |
| A | 0005575 | cellular_component | cellular_component |
| A | 0006198 | biological_process | cAMP catabolic process |
| A | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0047555 | molecular_function | 3',5'-cyclic-GMP phosphodiesterase activity |
| A | 1902660 | biological_process | negative regulation of glucose mediated signaling pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE SO4 A 401 |
| Chain | Residue |
| A | HIS130 |
| A | ZN404 |
| A | HOH501 |
| A | HOH518 |
| A | HOH701 |
| A | HOH742 |
| A | ASP132 |
| A | TRP175 |
| A | HIS213 |
| A | ASP244 |
| A | HIS294 |
| A | HIS326 |
| A | LYS328 |
| A | ZN403 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE MPD A 402 |
| Chain | Residue |
| A | ASN12 |
| A | ARG48 |
| A | PRO66 |
| A | SER67 |
| A | PHE68 |
| A | TYR69 |
| A | MET111 |
| A | SER329 |
| A | ARG337 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ZN A 403 |
| Chain | Residue |
| A | HIS128 |
| A | HIS130 |
| A | HIS213 |
| A | ASP244 |
| A | SO4401 |
| A | ZN404 |
| A | HOH501 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ZN A 404 |
| Chain | Residue |
| A | ASP132 |
| A | HIS133 |
| A | ASP244 |
| A | HIS326 |
| A | SO4401 |
| A | ZN403 |
| A | HOH501 |
Functional Information from PROSITE/UniProt
| site_id | PS00607 |
| Number of Residues | 15 |
| Details | PDEASE_II cAMP phosphodiesterases class-II signature. HpHLDHIsGLVVnSP |
| Chain | Residue | Details |
| A | HIS128-PRO142 | |
