4OJ2
The structure of aquaporin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| X | 0003091 | biological_process | renal water homeostasis |
| X | 0005372 | molecular_function | water transmembrane transporter activity |
| X | 0005515 | molecular_function | protein binding |
| X | 0005737 | cellular_component | cytoplasm |
| X | 0005794 | cellular_component | Golgi apparatus |
| X | 0005886 | cellular_component | plasma membrane |
| X | 0006833 | biological_process | water transport |
| X | 0007015 | biological_process | actin filament organization |
| X | 0015168 | molecular_function | glycerol transmembrane transporter activity |
| X | 0015250 | molecular_function | water channel activity |
| X | 0015267 | molecular_function | channel activity |
| X | 0015793 | biological_process | glycerol transmembrane transport |
| X | 0016020 | cellular_component | membrane |
| X | 0016323 | cellular_component | basolateral plasma membrane |
| X | 0016324 | cellular_component | apical plasma membrane |
| X | 0030658 | cellular_component | transport vesicle membrane |
| X | 0030659 | cellular_component | cytoplasmic vesicle membrane |
| X | 0031410 | cellular_component | cytoplasmic vesicle |
| X | 0048471 | cellular_component | perinuclear region of cytoplasm |
| X | 0051289 | biological_process | protein homotetramerization |
| X | 0055037 | cellular_component | recycling endosome |
| X | 0055085 | biological_process | transmembrane transport |
| X | 0070062 | cellular_component | extracellular exosome |
| X | 0071280 | biological_process | cellular response to copper ion |
| X | 0071288 | biological_process | cellular response to mercury ion |
| X | 0072205 | biological_process | metanephric collecting duct development |
| X | 0098576 | cellular_component | lumenal side of membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00221 |
| Number of Residues | 9 |
| Details | MIP MIP family signature. HINPAVTVA |
| Chain | Residue | Details |
| X | HIS66-ALA74 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 118 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"24733887","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4NEF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"24733887","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 21 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"24733887","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 21 |
| Details | Intramembrane: {"description":"Discontinuously helical","evidences":[{"source":"PubMed","id":"24733887","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4NEF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Motif: {"description":"NPA 1","evidences":[{"source":"PubMed","id":"24733887","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Motif: {"description":"NPA 2","evidences":[{"source":"PubMed","id":"24733887","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"PubMed","id":"12194985","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
