4OHC
Crystal structure of orotate phosphoribosyltransferase (OPRTase) from Burkholderia cenocepacia
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004588 | molecular_function | orotate phosphoribosyltransferase activity |
| A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| A | 0006222 | biological_process | UMP biosynthetic process |
| A | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
| A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004588 | molecular_function | orotate phosphoribosyltransferase activity |
| B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| B | 0006222 | biological_process | UMP biosynthetic process |
| B | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
| B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0004588 | molecular_function | orotate phosphoribosyltransferase activity |
| C | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| C | 0006222 | biological_process | UMP biosynthetic process |
| C | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
| C | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0004588 | molecular_function | orotate phosphoribosyltransferase activity |
| D | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| D | 0006222 | biological_process | UMP biosynthetic process |
| D | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
| D | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| E | 0000287 | molecular_function | magnesium ion binding |
| E | 0004588 | molecular_function | orotate phosphoribosyltransferase activity |
| E | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| E | 0006222 | biological_process | UMP biosynthetic process |
| E | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
| E | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| F | 0000287 | molecular_function | magnesium ion binding |
| F | 0004588 | molecular_function | orotate phosphoribosyltransferase activity |
| F | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| F | 0006222 | biological_process | UMP biosynthetic process |
| F | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
| F | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 301 |
| Chain | Residue |
| A | ASN113 |
| A | ILE116 |
| A | GLY118 |
| A | HIS119 |
| A | LEU120 |
| D | HOH474 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 302 |
| Chain | Residue |
| A | ARG125 |
| A | HOH522 |
| A | HOH568 |
| E | ARG53 |
| A | GLU73 |
| A | ILE75 |
| A | ASP76 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 303 |
| Chain | Residue |
| A | GLU63 |
| A | ARG95 |
| E | ARG56 |
| E | GLU60 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 304 |
| Chain | Residue |
| A | ARG56 |
| A | GLU60 |
| F | GLU63 |
| F | ARG95 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 301 |
| Chain | Residue |
| B | GLU73 |
| B | ILE75 |
| B | ASP76 |
| B | ARG125 |
| B | HOH468 |
| B | HOH588 |
| D | ARG53 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT B 302 |
| Chain | Residue |
| B | GLU63 |
| B | ARG95 |
| D | ARG56 |
| D | GLU60 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 303 |
| Chain | Residue |
| B | ASN113 |
| B | ILE116 |
| B | HOH430 |
| B | HOH482 |
| B | HOH495 |
| B | HOH549 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO C 301 |
| Chain | Residue |
| B | ARG53 |
| C | GLU73 |
| C | ILE75 |
| C | ASP76 |
| C | ARG125 |
| C | HOH483 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT C 302 |
| Chain | Residue |
| B | ARG56 |
| B | GLU60 |
| C | GLU63 |
| C | ARG95 |
| C | HOH542 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO D 301 |
| Chain | Residue |
| C | ARG53 |
| D | GLU73 |
| D | ILE75 |
| D | ASP76 |
| D | ARG125 |
| D | HOH583 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT D 302 |
| Chain | Residue |
| C | ARG56 |
| C | GLU60 |
| D | GLU63 |
| D | ARG95 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA D 303 |
| Chain | Residue |
| D | ASN113 |
| D | ILE116 |
| D | HOH557 |
| D | HOH562 |
| D | HOH580 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO E 301 |
| Chain | Residue |
| E | GLU73 |
| E | ILE75 |
| E | ASP76 |
| E | ARG125 |
| E | HOH582 |
| E | HOH583 |
| F | ARG53 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT E 302 |
| Chain | Residue |
| E | GLU63 |
| E | ARG95 |
| F | ARG56 |
| F | GLU60 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA E 303 |
| Chain | Residue |
| E | ASN113 |
| E | ILE116 |
| E | HOH441 |
| E | HOH442 |
| E | HOH536 |
| E | HOH590 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO F 301 |
| Chain | Residue |
| A | ARG53 |
| F | GLU73 |
| F | ILE75 |
| F | ASP76 |
| F | ARG125 |
| F | HOH571 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA F 302 |
| Chain | Residue |
| F | ASN113 |
| F | ILE116 |
| F | HOH531 |
| F | HOH532 |
| F | HOH534 |
| F | HOH602 |
