Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4OHC

Crystal structure of orotate phosphoribosyltransferase (OPRTase) from Burkholderia cenocepacia

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004588	molecular_function	orotate phosphoribosyltransferase activity
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006222	biological_process	UMP biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0019856	biological_process	pyrimidine nucleobase biosynthetic process
A	0044205	biological_process	'de novo' UMP biosynthetic process
B	0000287	molecular_function	magnesium ion binding
B	0004588	molecular_function	orotate phosphoribosyltransferase activity
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006222	biological_process	UMP biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0019856	biological_process	pyrimidine nucleobase biosynthetic process
B	0044205	biological_process	'de novo' UMP biosynthetic process
C	0000287	molecular_function	magnesium ion binding
C	0004588	molecular_function	orotate phosphoribosyltransferase activity
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006222	biological_process	UMP biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016757	molecular_function	glycosyltransferase activity
C	0019856	biological_process	pyrimidine nucleobase biosynthetic process
C	0044205	biological_process	'de novo' UMP biosynthetic process
D	0000287	molecular_function	magnesium ion binding
D	0004588	molecular_function	orotate phosphoribosyltransferase activity
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006222	biological_process	UMP biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016757	molecular_function	glycosyltransferase activity
D	0019856	biological_process	pyrimidine nucleobase biosynthetic process
D	0044205	biological_process	'de novo' UMP biosynthetic process
E	0000287	molecular_function	magnesium ion binding
E	0004588	molecular_function	orotate phosphoribosyltransferase activity
E	0006221	biological_process	pyrimidine nucleotide biosynthetic process
E	0006222	biological_process	UMP biosynthetic process
E	0016740	molecular_function	transferase activity
E	0016757	molecular_function	glycosyltransferase activity
E	0019856	biological_process	pyrimidine nucleobase biosynthetic process
E	0044205	biological_process	'de novo' UMP biosynthetic process
F	0000287	molecular_function	magnesium ion binding
F	0004588	molecular_function	orotate phosphoribosyltransferase activity
F	0006221	biological_process	pyrimidine nucleotide biosynthetic process
F	0006222	biological_process	UMP biosynthetic process
F	0016740	molecular_function	transferase activity
F	0016757	molecular_function	glycosyltransferase activity
F	0019856	biological_process	pyrimidine nucleobase biosynthetic process
F	0044205	biological_process	'de novo' UMP biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 301

Chain	Residue
A	ASN113
A	ILE116
A	GLY118
A	HIS119
A	LEU120
D	HOH474

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 302

Chain	Residue
A	ARG125
A	HOH522
A	HOH568
E	ARG53
A	GLU73
A	ILE75
A	ASP76

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT A 303

Chain	Residue
A	GLU63
A	ARG95
E	ARG56
E	GLU60

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT A 304

Chain	Residue
A	ARG56
A	GLU60
F	GLU63
F	ARG95

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO B 301

Chain	Residue
B	GLU73
B	ILE75
B	ASP76
B	ARG125
B	HOH468
B	HOH588
D	ARG53

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT B 302

Chain	Residue
B	GLU63
B	ARG95
D	ARG56
D	GLU60

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA B 303

Chain	Residue
B	ASN113
B	ILE116
B	HOH430
B	HOH482
B	HOH495
B	HOH549

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO C 301

Chain	Residue
B	ARG53
C	GLU73
C	ILE75
C	ASP76
C	ARG125
C	HOH483

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT C 302

Chain	Residue
B	ARG56
B	GLU60
C	GLU63
C	ARG95
C	HOH542

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO D 301

Chain	Residue
C	ARG53
D	GLU73
D	ILE75
D	ASP76
D	ARG125
D	HOH583

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT D 302

Chain	Residue
C	ARG56
C	GLU60
D	GLU63
D	ARG95

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA D 303

Chain	Residue
D	ASN113
D	ILE116
D	HOH557
D	HOH562
D	HOH580

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO E 301

Chain	Residue
E	GLU73
E	ILE75
E	ASP76
E	ARG125
E	HOH582
E	HOH583
F	ARG53

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT E 302

Chain	Residue
E	GLU63
E	ARG95
F	ARG56
F	GLU60

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA E 303

Chain	Residue
E	ASN113
E	ILE116
E	HOH441
E	HOH442
E	HOH536
E	HOH590

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO F 301

Chain	Residue
A	ARG53
F	GLU73
F	ILE75
F	ASP76
F	ARG125
F	HOH571

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA F 302

Chain	Residue
F	ASN113
F	ILE116
F	HOH531
F	HOH532
F	HOH534
F	HOH602

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)