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4OGT

Co-Crystal Structure of MDM2 with Inhbitor Compound 46

Functional Information from GO Data
ChainGOidnamespacecontents
A0005634cellular_componentnucleus
A0043066biological_processnegative regulation of apoptotic process
A0051726biological_processregulation of cell cycle
Functional Information from PDB Data
site_idAC1
Number of Residues14
DetailsBINDING SITE FOR RESIDUE 2U6 A 201
ChainResidue
ATHR16
AVAL110
AHOH302
AHOH320
AHOH357
AHOH390
AGLU23
ALEU54
AILE61
AMET62
AVAL93
AHIS96
ATYR104
AVAL109

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 A 202
ChainResidue
APRO20
AALA21
ATHR63
AHOH307
AHOH314
AHOH351
AHOH385

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues83
DetailsDomain: {"description":"SWIB/MDM2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01273","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

246031

PDB entries from 2025-12-10

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