4OGL
X-ray structure uridine phosphorylase from Vibrio cholerae in complex with thymine at 1.25 A resolution
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0004850 | molecular_function | uridine phosphorylase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0009116 | biological_process | nucleoside metabolic process |
A | 0009164 | biological_process | nucleoside catabolic process |
A | 0009166 | biological_process | nucleotide catabolic process |
A | 0016757 | molecular_function | glycosyltransferase activity |
A | 0016763 | molecular_function | pentosyltransferase activity |
A | 0044206 | biological_process | UMP salvage |
B | 0003824 | molecular_function | catalytic activity |
B | 0004850 | molecular_function | uridine phosphorylase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0009116 | biological_process | nucleoside metabolic process |
B | 0009164 | biological_process | nucleoside catabolic process |
B | 0009166 | biological_process | nucleotide catabolic process |
B | 0016757 | molecular_function | glycosyltransferase activity |
B | 0016763 | molecular_function | pentosyltransferase activity |
B | 0044206 | biological_process | UMP salvage |
C | 0003824 | molecular_function | catalytic activity |
C | 0004850 | molecular_function | uridine phosphorylase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0009116 | biological_process | nucleoside metabolic process |
C | 0009164 | biological_process | nucleoside catabolic process |
C | 0009166 | biological_process | nucleotide catabolic process |
C | 0016757 | molecular_function | glycosyltransferase activity |
C | 0016763 | molecular_function | pentosyltransferase activity |
C | 0044206 | biological_process | UMP salvage |
D | 0003824 | molecular_function | catalytic activity |
D | 0004850 | molecular_function | uridine phosphorylase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0009116 | biological_process | nucleoside metabolic process |
D | 0009164 | biological_process | nucleoside catabolic process |
D | 0009166 | biological_process | nucleotide catabolic process |
D | 0016757 | molecular_function | glycosyltransferase activity |
D | 0016763 | molecular_function | pentosyltransferase activity |
D | 0044206 | biological_process | UMP salvage |
E | 0003824 | molecular_function | catalytic activity |
E | 0004850 | molecular_function | uridine phosphorylase activity |
E | 0005737 | cellular_component | cytoplasm |
E | 0005829 | cellular_component | cytosol |
E | 0009116 | biological_process | nucleoside metabolic process |
E | 0009164 | biological_process | nucleoside catabolic process |
E | 0009166 | biological_process | nucleotide catabolic process |
E | 0016757 | molecular_function | glycosyltransferase activity |
E | 0016763 | molecular_function | pentosyltransferase activity |
E | 0044206 | biological_process | UMP salvage |
F | 0003824 | molecular_function | catalytic activity |
F | 0004850 | molecular_function | uridine phosphorylase activity |
F | 0005737 | cellular_component | cytoplasm |
F | 0005829 | cellular_component | cytosol |
F | 0009116 | biological_process | nucleoside metabolic process |
F | 0009164 | biological_process | nucleoside catabolic process |
F | 0009166 | biological_process | nucleotide catabolic process |
F | 0016757 | molecular_function | glycosyltransferase activity |
F | 0016763 | molecular_function | pentosyltransferase activity |
F | 0044206 | biological_process | UMP salvage |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE TDR A 301 |
Chain | Residue |
A | THR93 |
A | ILE220 |
A | GOL303 |
A | HOH402 |
A | THR94 |
A | GLY95 |
A | PHE161 |
A | GLN165 |
A | ARG167 |
A | GLU195 |
A | MET196 |
A | ILE219 |
site_id | AC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE EDO A 302 |
Chain | Residue |
A | ARG178 |
A | HOH408 |
A | HOH409 |
A | HOH603 |
A | HOH674 |
A | HOH721 |
B | LEU120 |
F | HOH626 |
site_id | AC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL A 303 |
Chain | Residue |
A | GLU197 |
A | TDR301 |
A | HOH459 |
A | HOH503 |
A | HOH527 |
A | HOH723 |
B | HIS7 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA A 304 |
Chain | Residue |
A | GLU48 |
A | ILE68 |
A | SER72 |
B | GLU48 |
B | ILE68 |
B | SER72 |
site_id | AC5 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE TDR B 301 |
Chain | Residue |
B | GLY95 |
B | PHE161 |
B | GLN165 |
B | ARG167 |
B | GLU195 |
B | MET196 |
B | ILE220 |
B | TRS303 |
B | HOH418 |
B | HOH732 |
site_id | AC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO B 302 |
Chain | Residue |
B | PHE6 |
B | HIS7 |
B | GLY9 |
B | HIS46 |
B | HOH711 |
site_id | AC7 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE TRS B 303 |
Chain | Residue |
A | HIS7 |
A | ARG47 |
B | ILE68 |
B | THR93 |
B | GLU195 |
B | MET196 |
B | GLU197 |
B | TDR301 |
B | HOH467 |
B | HOH509 |
site_id | AC8 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE TDR C 301 |
Chain | Residue |
C | THR94 |
C | GLY95 |
C | PHE161 |
C | GLN165 |
C | ARG167 |
C | PHE194 |
C | GLU195 |
C | MET196 |
C | ILE220 |
C | GOL305 |
C | HOH408 |
site_id | AC9 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE EDO C 302 |
Chain | Residue |
B | HOH724 |
C | ARG178 |
C | HOH414 |
C | HOH417 |
C | HOH643 |
C | HOH649 |
C | HOH683 |
D | LEU120 |
site_id | BC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO C 303 |
Chain | Residue |
C | ASP132 |
C | HOH407 |
C | HOH426 |
C | HOH554 |
C | HOH766 |
site_id | BC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO C 304 |
Chain | Residue |
C | LYS3 |
C | GLN82 |
C | HOH674 |
D | ASP169 |
D | THR170 |
D | PHE171 |
D | HOH544 |
site_id | BC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL C 305 |
Chain | Residue |
C | PHE161 |
C | GLU197 |
C | TDR301 |
C | HOH476 |
C | HOH491 |
D | HIS7 |
site_id | BC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA C 306 |
Chain | Residue |
D | ILE68 |
D | SER72 |
C | GLU48 |
C | ILE68 |
C | SER72 |
D | GLU48 |
site_id | BC5 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE TDR D 301 |
Chain | Residue |
D | THR94 |
D | GLY95 |
D | PHE161 |
D | GLN165 |
D | ARG167 |
D | GLU195 |
D | MET196 |
D | ILE220 |
D | GOL302 |
D | HOH409 |
site_id | BC6 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE GOL D 302 |
Chain | Residue |
C | HIS7 |
C | ARG47 |
D | ILE68 |
D | PHE161 |
D | GLU197 |
D | TDR301 |
D | GOL303 |
D | HOH452 |
D | HOH468 |
site_id | BC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL D 303 |
Chain | Residue |
C | ARG47 |
C | HOH791 |
D | PHE161 |
D | GLU226 |
D | GOL302 |
site_id | BC8 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE TDR E 301 |
Chain | Residue |
E | GLY95 |
E | PHE161 |
E | GLN165 |
E | ARG167 |
E | GLU195 |
E | MET196 |
E | ILE220 |
E | GOL304 |
E | HOH421 |
E | HOH485 |
E | HOH545 |
E | HOH742 |
site_id | BC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO E 302 |
Chain | Residue |
C | HOH501 |
D | MET125 |
E | MET125 |
E | HOH744 |
site_id | CC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE EDO E 303 |
Chain | Residue |
E | ARG178 |
E | HOH407 |
E | HOH420 |
E | HOH581 |
E | HOH598 |
E | HOH664 |
E | HOH745 |
F | LEU120 |
site_id | CC2 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE GOL E 304 |
Chain | Residue |
E | ILE68 |
E | THR93 |
E | PHE161 |
E | MET196 |
E | GLU197 |
E | TDR301 |
E | HOH453 |
E | HOH655 |
F | HIS7 |
F | HOH646 |
site_id | CC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA E 305 |
Chain | Residue |
E | GLU48 |
E | ILE68 |
E | SER72 |
F | GLU48 |
F | ILE68 |
F | SER72 |
site_id | CC4 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE TDR F 301 |
Chain | Residue |
F | THR93 |
F | THR94 |
F | GLY95 |
F | PHE161 |
F | GLN165 |
F | ARG167 |
F | GLU195 |
F | MET196 |
F | ILE219 |
F | ILE220 |
F | GOL304 |
F | HOH406 |
site_id | CC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO F 302 |
Chain | Residue |
F | GLY17 |
F | GLN59 |
F | SER60 |
F | HOH461 |
site_id | CC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO F 303 |
Chain | Residue |
A | MET125 |
A | HOH461 |
E | HOH493 |
F | MET125 |
site_id | CC7 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL F 304 |
Chain | Residue |
E | HIS7 |
F | PHE161 |
F | GLU197 |
F | TDR301 |
F | HOH468 |
F | HOH470 |
F | HOH557 |
Functional Information from PROSITE/UniProt
site_id | PS01232 |
Number of Residues | 16 |
Details | PNP_UDP_1 Purine and other phosphorylases family 1 signature. StGIGgPStSIaveEL |
Chain | Residue | Details |
A | SER65-LEU80 |