Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4OGK

X-ray structure of the uridine phosphorylase from Salmonella typhimurium in complex with thymidine at 2.40 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004850	molecular_function	uridine phosphorylase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0009116	biological_process	nucleoside metabolic process
A	0009164	biological_process	nucleoside catabolic process
A	0009166	biological_process	nucleotide catabolic process
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
A	0044206	biological_process	UMP salvage
A	0047847	molecular_function	deoxyuridine phosphorylase activity
B	0003824	molecular_function	catalytic activity
B	0004850	molecular_function	uridine phosphorylase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0009116	biological_process	nucleoside metabolic process
B	0009164	biological_process	nucleoside catabolic process
B	0009166	biological_process	nucleotide catabolic process
B	0016757	molecular_function	glycosyltransferase activity
B	0016763	molecular_function	pentosyltransferase activity
B	0044206	biological_process	UMP salvage
B	0047847	molecular_function	deoxyuridine phosphorylase activity
C	0003824	molecular_function	catalytic activity
C	0004850	molecular_function	uridine phosphorylase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0009116	biological_process	nucleoside metabolic process
C	0009164	biological_process	nucleoside catabolic process
C	0009166	biological_process	nucleotide catabolic process
C	0016757	molecular_function	glycosyltransferase activity
C	0016763	molecular_function	pentosyltransferase activity
C	0044206	biological_process	UMP salvage
C	0047847	molecular_function	deoxyuridine phosphorylase activity
D	0003824	molecular_function	catalytic activity
D	0004850	molecular_function	uridine phosphorylase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0009116	biological_process	nucleoside metabolic process
D	0009164	biological_process	nucleoside catabolic process
D	0009166	biological_process	nucleotide catabolic process
D	0016757	molecular_function	glycosyltransferase activity
D	0016763	molecular_function	pentosyltransferase activity
D	0044206	biological_process	UMP salvage
D	0047847	molecular_function	deoxyuridine phosphorylase activity
E	0003824	molecular_function	catalytic activity
E	0004850	molecular_function	uridine phosphorylase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0009116	biological_process	nucleoside metabolic process
E	0009164	biological_process	nucleoside catabolic process
E	0009166	biological_process	nucleotide catabolic process
E	0016757	molecular_function	glycosyltransferase activity
E	0016763	molecular_function	pentosyltransferase activity
E	0044206	biological_process	UMP salvage
E	0047847	molecular_function	deoxyuridine phosphorylase activity
F	0003824	molecular_function	catalytic activity
F	0004850	molecular_function	uridine phosphorylase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0009116	biological_process	nucleoside metabolic process
F	0009164	biological_process	nucleoside catabolic process
F	0009166	biological_process	nucleotide catabolic process
F	0016757	molecular_function	glycosyltransferase activity
F	0016763	molecular_function	pentosyltransferase activity
F	0044206	biological_process	UMP salvage
F	0047847	molecular_function	deoxyuridine phosphorylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE THM A 301

Chain	Residue
A	ILE69
A	ARG91
A	THR94
A	GLN166
A	MET197
A	GLU198
A	ILE220
B	ARG48

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IPA A 302

Chain	Residue
C	ALA36

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE THM B 301

Chain	Residue
A	HIS8
A	ARG48
B	THR94
B	PHE162
B	GLN166
B	ARG168
B	TYR195
B	GLU196
B	GLU198
B	VAL221

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO C 301

Chain	Residue
C	HIS101
C	VAL153

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE THM D 301

Chain	Residue
C	PHE7
C	HIS8
C	ARG48
D	ILE69
D	THR94
D	PHE162
D	GLN166
D	ARG168
D	TYR195
D	GLU196
D	MET197
D	GLU198

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PEG D 302

Chain	Residue
A	THR233
D	ASN230

site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE THM E 301

Chain	Residue
E	ILE69
E	ARG91
E	THR94
E	GLY96
E	PHE162
E	GLN166
E	TYR195
E	GLU196
E	GLU198
E	ILE220
E	VAL221

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PG4 E 302

Chain	Residue
D	HIS101
D	VAL153
E	PRO100
E	VAL131
E	ALA132
E	ASP133

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO E 303

Chain	Residue
A	LYS60
E	ALA231
E	GLU232

site_id	BC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE THM F 301

Chain	Residue
E	HIS8
F	PHE162
F	GLN166
F	ARG168
F	TYR195
F	GLU196
F	MET197
F	GLU198
F	VAL221

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K F 302

Chain	Residue
E	GLU49
E	ILE69
E	SER73
F	GLU49
F	ILE69
F	SER73

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO F 303

Chain	Residue
F	HIS101
F	VAL153

Functional Information from PROSITE/UniProt

site_id	PS01232
Number of Residues	16
Details	PNP_UDP_1 Purine and other phosphorylases family 1 signature. StGIGgPStSIaveEL

Chain	Residue	Details
A	SER66-LEU81

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)