4OGK
X-ray structure of the uridine phosphorylase from Salmonella typhimurium in complex with thymidine at 2.40 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004850 | molecular_function | uridine phosphorylase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0009166 | biological_process | nucleotide catabolic process |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0044206 | biological_process | UMP salvage |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004850 | molecular_function | uridine phosphorylase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0009166 | biological_process | nucleotide catabolic process |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0044206 | biological_process | UMP salvage |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004850 | molecular_function | uridine phosphorylase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0009116 | biological_process | nucleoside metabolic process |
| C | 0009166 | biological_process | nucleotide catabolic process |
| C | 0016763 | molecular_function | pentosyltransferase activity |
| C | 0044206 | biological_process | UMP salvage |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004850 | molecular_function | uridine phosphorylase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0009116 | biological_process | nucleoside metabolic process |
| D | 0009166 | biological_process | nucleotide catabolic process |
| D | 0016763 | molecular_function | pentosyltransferase activity |
| D | 0044206 | biological_process | UMP salvage |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004850 | molecular_function | uridine phosphorylase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0009116 | biological_process | nucleoside metabolic process |
| E | 0009166 | biological_process | nucleotide catabolic process |
| E | 0016763 | molecular_function | pentosyltransferase activity |
| E | 0044206 | biological_process | UMP salvage |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004850 | molecular_function | uridine phosphorylase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0009116 | biological_process | nucleoside metabolic process |
| F | 0009166 | biological_process | nucleotide catabolic process |
| F | 0016763 | molecular_function | pentosyltransferase activity |
| F | 0044206 | biological_process | UMP salvage |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE THM A 301 |
| Chain | Residue |
| A | ILE69 |
| A | ARG91 |
| A | THR94 |
| A | GLN166 |
| A | MET197 |
| A | GLU198 |
| A | ILE220 |
| B | ARG48 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IPA A 302 |
| Chain | Residue |
| C | ALA36 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE THM B 301 |
| Chain | Residue |
| A | HIS8 |
| A | ARG48 |
| B | THR94 |
| B | PHE162 |
| B | GLN166 |
| B | ARG168 |
| B | TYR195 |
| B | GLU196 |
| B | GLU198 |
| B | VAL221 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO C 301 |
| Chain | Residue |
| C | HIS101 |
| C | VAL153 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE THM D 301 |
| Chain | Residue |
| C | PHE7 |
| C | HIS8 |
| C | ARG48 |
| D | ILE69 |
| D | THR94 |
| D | PHE162 |
| D | GLN166 |
| D | ARG168 |
| D | TYR195 |
| D | GLU196 |
| D | MET197 |
| D | GLU198 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG D 302 |
| Chain | Residue |
| A | THR233 |
| D | ASN230 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE THM E 301 |
| Chain | Residue |
| E | ILE69 |
| E | ARG91 |
| E | THR94 |
| E | GLY96 |
| E | PHE162 |
| E | GLN166 |
| E | TYR195 |
| E | GLU196 |
| E | GLU198 |
| E | ILE220 |
| E | VAL221 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PG4 E 302 |
| Chain | Residue |
| D | HIS101 |
| D | VAL153 |
| E | PRO100 |
| E | VAL131 |
| E | ALA132 |
| E | ASP133 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO E 303 |
| Chain | Residue |
| A | LYS60 |
| E | ALA231 |
| E | GLU232 |
| site_id | BC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE THM F 301 |
| Chain | Residue |
| E | HIS8 |
| F | PHE162 |
| F | GLN166 |
| F | ARG168 |
| F | TYR195 |
| F | GLU196 |
| F | MET197 |
| F | GLU198 |
| F | VAL221 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K F 302 |
| Chain | Residue |
| E | GLU49 |
| E | ILE69 |
| E | SER73 |
| F | GLU49 |
| F | ILE69 |
| F | SER73 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO F 303 |
| Chain | Residue |
| F | HIS101 |
| F | VAL153 |
Functional Information from PROSITE/UniProt
| site_id | PS01232 |
| Number of Residues | 16 |
| Details | PNP_UDP_1 Purine and other phosphorylases family 1 signature. StGIGgPStSIaveEL |
| Chain | Residue | Details |
| A | SER66-LEU81 |
